The Role of Caspase-11 and Pyroptosis in the Regulation of Inflammation in Peri-Implantitis

• Published in: Journal of inflammation research Vol. 16; pp. 4471 - 4479
• Main Authors: Jiao, Pengcheng, Li, Zuntai, Li, Birong, Jiao, Xingyuan
• Format: Journal Article
• Language: English
• Published: Dove Medical Press Limited 31.10.2023; Dove; Dove Medical Press
• Subjects: Analysis; caspase-11; Health aspects; Inflammation; peri-implantitis; pyroptosis; Review; China
• ISSN: 1178-7031; 1178-7031
• DOI: 10.2147/JIR.S427523

Peri-implantitis is an important cause of oral implant failure. In the past, TLR4 and TLR2 in the Toll-like family were generally considered as the key immune recognition receptors regulating peri-implantitis. However, under the guidance of this theory, there are still some unexplainable peri-implantitis symptoms. With the discovery of novel intracellular LPS receptor Caspase-11, a new understanding of inflammatory signaling and immune regulation in the development of peri-implantitis has been gained. However, the regulatory role of Caspase-11 in peri-implantitis and its crosstalk with the TLR4 pathway remain unclear. The therapeutic effect of drugs targeting Caspase-11 on peri-implantitis is still in its early stages. In view of this situation, this paper reviews the possible role of Caspase-11 in peri-implant inflammation, elaborated the entry process of LPS and the activation mechanism of Caspase-11, and analyzes the differences in Caspase-11 between commonly studied animals, mice and humans. The current research hotspots and challenges are also analyzed to provide new insights and ideas for researchers. Keywords: caspase-11, pyroptosis, inflammation, peri-implantitis