Enterococcus faecium Regulates Honey Bee Developmental Genes

• Published in: International journal of molecular sciences Vol. 22; no. 22; p. 12105
• Main Authors: Du, Yating, Luo, Shiqi, Zhou, Xin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.11.2021; MDPI
• Subjects: Agricultural ecosystems; Agricultural products; Animals; Antimicrobial agents; Apis mellifera; Bacteria; Bees; Bees - genetics; Bees - microbiology; Chromosomes; Drug resistance; Ecosystem; Enterococcus faecium; Enterococcus faecium - genetics; Gastrointestinal Microbiome - genetics; Gene expression; Gene Expression Regulation, Developmental - genetics; Genes; Genomes; Gram-positive bacteria; gut bacteria; honey bee; Host-Pathogen Interactions - genetics; Infections; Information processing; Lactic acid; Metabolism; Microbiota; MicroRNAs; MicroRNAs - genetics; miRNA; Nucleotide sequence; Pollination; Post-transcription; Probiotics; Proteins; transcriptome; Transcriptome - genetics; Transcriptomes; Enterococcus faecium; gut bacteria; miRNA; honey bee; transcriptome
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms222212105

Honey bees provide essential pollination services to the terrestrial ecosystem and produce important agricultural products. As a beneficial lactic acid bacterium, is often supplied as a probiotic for honey bees and other animals. However, the underlying mechanisms of its actions and possible safety risks are not well understood. We present the first complete genome sequence of isolated from the honey bee gut using nanopore sequencing, and investigate the effects and mechanisms of interactions between and honey bees via transcriptome and miRNA analysis. colonization increased honey bee gut weight. Transcriptome analysis showed that developmental genes were up-regulated. In accordance, the target genes of the down-regulated miRNAs were enriched in developmental pathways. We describe how increases honey bee gut weight at the transcriptional and post-transcriptional levels, and add insights about how miRNAs mediate host and bacteria interactions.