Big steps toward understanding dynein

• Published in: The Journal of cell biology Vol. 202; no. 1; pp. 15 - 23
• Main Author: Kikkawa, Masahide
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 08.07.2013; The Rockefeller University Press
• Subjects: Adenosine Triphosphate - chemistry; Animals; Axoneme - chemistry; Binding Sites; Biomechanical Phenomena; Cell division; Chlamydomonas reinhardtii - chemistry; Cilia - chemistry; Crystallography; Dyneins - chemistry; Dyneins - physiology; Flagella - chemistry; Models, Molecular; Molecules; Multiprotein Complexes - chemistry; Protein Structure, Tertiary; Proteins; Reviews; Structure-Activity Relationship

Dynein is a microtubule-based molecular motor that is involved in various biological functions, such as axonal transport, mitosis, and cilia/flagella movement. Although dynein was discovered 50 years ago, the progress of dynein research has been slow due to its large size and flexible structure. Rec...