Big steps toward understanding dynein

Dynein is a microtubule-based molecular motor that is involved in various biological functions, such as axonal transport, mitosis, and cilia/flagella movement. Although dynein was discovered 50 years ago, the progress of dynein research has been slow due to its large size and flexible structure. Rec...

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Bibliographic Details
Published inThe Journal of cell biology Vol. 202; no. 1; pp. 15 - 23
Main Author Kikkawa, Masahide
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 08.07.2013
The Rockefeller University Press
Subjects
Adenosine Triphosphate - chemistry
Animals
Axoneme - chemistry
Binding Sites
Biomechanical Phenomena
Cell division
Chlamydomonas reinhardtii - chemistry
Cilia - chemistry
Crystallography
Dyneins - chemistry
Dyneins - physiology
Flagella - chemistry
Models, Molecular
Molecules
Multiprotein Complexes - chemistry
Protein Structure, Tertiary
Proteins
Reviews
Structure-Activity Relationship
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Summary:Dynein is a microtubule-based molecular motor that is involved in various biological functions, such as axonal transport, mitosis, and cilia/flagella movement. Although dynein was discovered 50 years ago, the progress of dynein research has been slow due to its large size and flexible structure. Recent progress in understanding the force-generating mechanism of dynein using x-ray crystallography, cryo-electron microscopy, and single molecule studies has provided key insight into the structure and mechanism of action of this complex motor protein.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.201304099