Melphalan dose in myeloma patients ≥65 years of age undergoing high-dose therapy and autologous stem cell transplantation: a multicentric observational registry study

• Published in: Bone marrow transplantation (Basingstoke) Vol. 54; no. 7; pp. 1029 - 1037
• Main Authors: Ghilardi, Guido, Pabst, Thomas, Jeker, Barbara, Müller, Rouven, Cairoli, Anne, Müller, Antonia M. S., Bargetzi, Mario, Hitz, Felicitas, Baldomero, Helen, Heim, Dominik, Schmidt, Adrian, Rossi, Davide, Ghielmini, Michele, Wannesson, Luciano, Lerch, Erika, Samaras, Panagiotis, Schanz, Urs, Passweg, Jakob R., Stussi, Georg, Kleber, Martina, Gerber, Bernhard
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2019; Nature Publishing Group
• Subjects: 13/100; 692/699/1541/1990/804; 692/700/565/1436/99; 692/700/565/2319; Autografts; Bone marrow; Cell Biology; Cytogenetics; Geriatrics; Hematology; Hematopoietic stem cells; Internal Medicine; Medicine; Medicine & Public Health; Melphalan; Multiple myeloma; Multivariate analysis; Older people; Public Health; Remission; Renal function; Stem cell transplantation; Stem Cells; Survival; Transplantation
• ISSN: 0268-3369; 1476-5365
• DOI: 10.1038/s41409-018-0379-y

The optimal melphalan dose prior to autologous stem cell transplantation (ASCT) is not known for elderly multiple myeloma (MM) patients. We analyzed data of all MM patients ≥65 years ( n  = 388) enrolled in the observational Swiss Blood Stem Cell Transplantation Registry. The median age was 67 years (65–77). Single ASCT was performed in 344 (88.7%) patients, with 259 patients (75.3%) receiving a melphalan dose of 200 mg/m 2 (MEL200), and 85 patients (24.7%) receiving lower doses (MELlow) (median 140 mg/m 2 , range 70−180 mg/m 2 ). MEL200 patients were slightly younger, and had a better renal function, but did not differ with regards to ISS stage, cytogenetic risk, remission status, and KPS. Overall mortality at day 100 was 1.5% without differences between the MEL groups ( p  = 0.621). Median progression-free survival (PFS) in the MEL200 and the MELlow group was 27.7 and 22.1 months, respectively ( p  = 0.294). Median overall survival (OS) in the MEL200 and in MELlow group was 91.2 and 61.2 months ( p  = 0.015). However, multivariate analysis showed no significant association of the melphalan dose and OS (HR 0.734; CI95% 0.264–2.038; p  = 0.553). In conclusion, our data reveal no significant differences in safety and PFS for elderly myeloma patients treated with MEL200 or with lower MEL doses.