Ethical, social, and cultural issues related to clinical genetic testing and counseling in low- and middle-income countries: a systematic review

• Published in: Genetics in medicine Vol. 23; no. 12; pp. 2270 - 2280
• Main Authors: Zhong, Adrina, Darren, Benedict, Loiseau, Bethina, He, Li Qun Betty, Chang, Trillium, Hill, Jessica, Dimaras, Helen
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.12.2021; Elsevier Limited
• Subjects: Biomedical and Life Sciences; Biomedicine; Ethics; Genetic counseling; Genetic disorders; Human Genetics; Laboratory Medicine; Low income groups; Systematic Review; Global health; Genetics; Genetic counseling; Genetic testing; Low- and middle-income countries
• ISSN: 1098-3600; 1530-0366
• DOI: 10.1038/s41436-018-0090-9

Purpose We performed a systematic review of the ethical, social, and cultural issues associated with delivery of genetic services in low- and middle-income countries (LMICs). Methods We searched 11 databases for studies addressing ethical, social, and/or cultural issues associated with clinical genetic testing and/or counselling performed in LMICs. Narrative synthesis was employed to analyze findings, and resultant themes were mapped onto the social ecological model (PROSPERO #CRD42016042894). Results After reviewing 13,308 articles, 192 met inclusion criteria. Nine themes emerged: (1) genetic counseling has a tendency of being directive, (2) genetic services have psychosocial consequences that require improved support, (3) medical genetics training is inadequate, (4) genetic services are difficult to access, (5) social determinants affect uptake and understanding of genetic services, (6) social stigma is often associated with genetic disease, (7) family values are at risk of disruption by genetic services, (8) religious principles pose barriers to acceptability and utilization of genetic services, and (9) cultural beliefs and practices influence uptake of information and understanding of genetic disease. Conclusion We identified a number of complex and interrelated ethical, cultural, and social issues with implications implications for further development of genetic services in LMICs.