Role of Indocyanine Green in Sentinel Node Mapping in Gynecologic Cancer: Is Fluorescence Imaging the New Standard?

• Published in: Journal of minimally invasive gynecology Vol. 23; no. 2; p. 186
• Main Authors: Darin, María Cecilia, Gómez-Hidalgo, Natalia Rodriguez, Westin, Shannon N, Soliman, Pamela T, Escobar, Pedro F, Frumovitz, Michael, Ramirez, Pedro T
• Format: Journal Article
• Language: English
• Published: United States 01.02.2016
• Subjects: Coloring Agents; Endometrial Neoplasms - pathology; Female; Genital Neoplasms, Female - pathology; Humans; Indocyanine Green; Lymph Node Excision; Lymph Nodes - pathology; Optical Imaging; Sentinel Lymph Node Biopsy - methods; Sentinel Lymph Node Biopsy - standards; Uterine Cervical Neoplasms - pathology; Uterine Neoplasms - pathology; Vulvar Neoplasms - pathology; Indocyanine green; Laparoscopy; Lymphatic mapping; Robotics
• ISSN: 1553-4669
• DOI: 10.1016/j.jmig.2015.10.011

Sentinel lymph node biopsy has proven safe and feasible in a number of gynecologic cancers such as vulvar cancer, cervical cancer, and endometrial cancer. The proposed aim of lymphatic mapping and sentinel node identification is to decrease the associated morbidity of a complete lymphadenectomy, particularly the rate of lymphedema, while also increasing the detection of small tumor deposits in the node. Different tracers have been shown to be useful, including technetium-99 and blue dye, with a detection reported in 66% to 86%. Recently, there has been increasing interest in the use of fluorescent dies such as indocyanine green (ICG). In this report we provide a review of the existing literature regarding the use of ICG in cervical or endometrial cancer with the goal to provide details on its utility and compare it with other tracers.