Plants with anti-Leishmania activity: Integrative review from 2000 to 2011

The search for more effective new drugs to treat Leishmaniasis is undoubtedly relevant. Our objective in this study was to investigate research publications addressing plants with anti-Leishmaniasis activity. An integrative review of the literature from 2000 to 2011 was carried out in the databases...

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Published inPharmacognosy reviews Vol. 7; no. 13; pp. 34 - 41
Main Authors Brito, Ana Maria, Santos, Derivaldo, Rodrigues, Sheyla, Brito, Renan, Xavier-Filho, Lauro
Format Journal Article
LanguageEnglish
Published India Medknow Publications Pvt Ltd 01.01.2013
Medknow Publications and Media Pvt. Ltd
Phcog.net
Medknow Publications & Media Pvt Ltd
Subjects
Antibiotics
Care and treatment
Herbal medicine
Leishmaniasis
Medicinal plants
Parasitic diseases
Pharmacology
Review
India
scientific and technical publications
natural products
Anti-Leishmania activity
plants
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Summary:The search for more effective new drugs to treat Leishmaniasis is undoubtedly relevant. Our objective in this study was to investigate research publications addressing plants with anti-Leishmaniasis activity. An integrative review of the literature from 2000 to 2011 was carried out in the databases such as Latin-American and Caribbean Health Sciences (LILACS), Scientific Electronic Library Online (SciELO), and Medical Literature Analysis and Retrieval System Online (MEDLINE). In the initial search, 150 articles were found, with 25 based in LILACS, 68 in SciELO, and 46 in MEDLINE. From these data, after reading the abstracts that were available online, we excluded 12 from LILACS, 39 from SciELO, and 28 from MEDLINE for presenting article duplications. This left 61 articles to be read; however, only 18 of them answered the research questions and determined the final sample of this review. The results showed that research involving the search for new drugs against Leishmaniasis should be intensified, especially for the amastigote form, and studies with in vivo tests could become a great strategy for successfully finding new treatments for Leishmaniasis. It is believed that it is extremely important and urgent to conduct more trials in search of new effective drugs against Leishmaniasis that possess minimal adverse effects and that are easily accessible to the public.
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ISSN:0973-7847
0976-2787
DOI:10.4103/0973-7847.112840