Downregulation of metabotropic glutamate receptor 1a in motoneurons after axotomy
Axotomized motoneurons display drastic modifications in synaptic structure and function related to their disconnection from the periphery and establishment of a regenerative metabolic functional mode. The molecular basis of these modifications is not fully understood. Here we describe changes in met...
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Published in | Neuroreport Vol. 8; no. 7; p. 1711 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
06.05.1997
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Subjects | |
Online Access | Get more information |
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Summary: | Axotomized motoneurons display drastic modifications in synaptic structure and function related to their disconnection from the periphery and establishment of a regenerative metabolic functional mode. The molecular basis of these modifications is not fully understood. Here we describe changes in metabotropic glutamate receptor 1a (mGluR1a)-immunoreactivity 3, 7 or 14 days after unilateral aciatic transection. mGluR1a-immunoreactivity was distributed throughout the somatic cytoplasm and somatodendritic membrane of uninjured motoneurons and was significantly reduced in axotomized motoneurons. This reduction was observed at 3 days and grew progressively over 2 weeks. These findings suggest that downregulation of mGluR1a could contribute to reduced excitatory neurotransmission in axotomized motoneurons. |
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ISSN: | 0959-4965 |
DOI: | 10.1097/00001756-199705060-00029 |