Hemodynamic and Metabolic Effects of Hypertonic Saline Infusion in Normovolemic Dogs

• Published in: Kita Kantō igaku (The Kitakanto Medical Journal) Vol. 54; no. 2; pp. 109 - 112
• Main Authors: Ishikawa, Susumu, Oki, Shigeru, Oshima, Kiyohiro, Muraoka, Masato, Murakami, Jun, Nameki, Taro, Sugano, Masayuki, Hasegawa, Yutaka, Takahashi, Toru, Morishita, Yasuo
• Format: Journal Article
• Language: English; Japanese
• Published: The Kitakanto Medical Society 2004
• Subjects: electrolyte; hemodynamic effect; hypertonic saline; metabolic effect
• ISSN: 1343-2826; 1881-1191
• DOI: 10.2974/kmj.54.109

Aims : The hemodynamic and metabolic effects of hypertonic saline (HTS) infusion were studied in normovolemic dogs. Methods : Seven adult mongrel dogs, weighing 10 to 15kg, were used in this study. Under general anesthesia, the pericardium was opened via a right thoracotomy. High-dosage of HTS (10% NaCl, 5ml/kg) was infused intravenously within a five minute period. Results : Systemic blood pressure significantly increased from 110± 10mmHg to 125 ± 10mmHg. Central venous pressure and left atrial pressure also significantly increased (4.6 ± 1.7 → 9.3±1.9mmHg, 3.5 ± 1.4 → 5.7 ± 2.4mmHg, respectively). Cardiac output increased significantly from 2.0±0.2L/min to 3.0±0.2L/min 10 minutes after HTS infusion. Arterial blood gas analysis revealed that pH, base excess and HCO3- had decreased significantly 10 minutes after HTS infusion. Hemoglobin and hematocrit levels significantly decreased after HTS infusion. Although O2 content decreased significantly, the myocardial O2 extraction rate did not change. Serum sodium and chloride values increased significantly and sustained those levels until 60 minutes after HTS infusion. Conclusions : In conclusion, HTS infusion remains a simple and valuable clinical procedure to use in restoring adequate hemodynamic conditions after hypovolemic shock.