Tutorial on Monoclonal Antibody Pharmacokinetics and Its Considerations in Early Development

The tutorial introduces the readers to the fundamentals of antibody pharmacokinetics (PK) in the context of drug development. Topics covered include an overview of antibody development, PK characteristics, and the application of antibody PK/pharmacodynamics (PD) in research and development decision‐...

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Bibliographic Details
Published inClinical and translational science Vol. 11; no. 6; pp. 540 - 552
Main Authors Ovacik, Meric, Lin, Kedan
Format Journal Article
LanguageEnglish
Published United States John Wiley and Sons Inc 01.11.2018
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Tutorial
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Summary:The tutorial introduces the readers to the fundamentals of antibody pharmacokinetics (PK) in the context of drug development. Topics covered include an overview of antibody development, PK characteristics, and the application of antibody PK/pharmacodynamics (PD) in research and development decision‐making. We also discuss the general considerations for planning a nonclinical PK program and describe the types of PK studies that should be performed during early development of monoclonal antibodies.
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ISSN:1752-8054
1752-8062
1752-8062
DOI:10.1111/cts.12567