Catalytic Silylations of Alcohols: Turning Simple Protecting-Group Strategies into Powerful Enantioselective Synthetic Methods

In recent years, remarkable progress has been made in the enantioselective silylation of alcohols. Owing to the successful site‐ and stereoselective functionalization of hydroxy groups, silyl ether formations have evolved from being a simple reaction for functional‐group protection into a powerful e...

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Published inAngewandte Chemie International Edition Vol. 54; no. 33; pp. 9456 - 9466
Main Authors Xu, Li-Wen, Chen, Yun, Lu, Yixin
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 10.08.2015
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Alcohols
asymmetric catalysis
Catalysis
Catalysts
desymmetrization
enantioselectivity
Ethers
Evolution
Formations
kinetic resolution
Silicon
silylation
Strategy
enantioselectivity
kinetic resolution
desymmetrization
asymmetric catalysis
silylation
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Summary:In recent years, remarkable progress has been made in the enantioselective silylation of alcohols. Owing to the successful site‐ and stereoselective functionalization of hydroxy groups, silyl ether formations have evolved from being a simple reaction for functional‐group protection into a powerful enantioselective process. In this Minireview, we highlight important recent findings in this emerging field. Silicon talks: Owing to the development of methods for the site‐ and stereoselective functionalization of hydroxy groups, silyl ether formation has evolved from being a simple reaction for functional‐group protection into a powerful enantioselective process. This Minireview highlights recent findings in the emerging field of enantioselective alcohol silylation.
Bibliography:Fundamental Research Funds for the Central Universities - No. GK201501005
Singapore A*STAR SERC Public Sector Research Funding - No. R-143-000-618-305
National Natural Science Foundation of China - No. 21173064; No. 21472031
National University of Singapore - No. R143-000-599-112
ArticleID:ANIE201504127
Zhejiang Provincial Natural Science Foundation of China - No. LR14B030001
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201504127