Region-of-interest-based analysis with application of cortical thickness variation of left planum temporale in schizophrenia and psychotic bipolar disorder

• Published in: Human brain mapping Vol. 29; no. 8; pp. 973 - 985
• Main Authors: Qiu, Anqi, Vaillant, Marc, Barta, Patrick, Ratnanather, J.Tilak, Miller, Michael I.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.08.2008; Wiley-Liss
• Subjects: Adult; Biological and medical sciences; Bipolar Disorder - pathology; Bipolar Disorder - physiopathology; Cerebral Cortex - pathology; Cerebral Cortex - physiology; Cognition. Intelligence; cortical thickness; Female; Fundamental and applied biological sciences. Psychology; Gaussian random field; Humans; Investigative techniques, diagnostic techniques (general aspects); Laplace-Beltrami operator; LDDMM; Male; Medical sciences; Mental imagery. Mental representation; Middle Aged; Nervous system; planum temporale; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; psychotic bipolar disorder; Psychotic Disorders - pathology; Psychotic Disorders - physiopathology; Radiodiagnosis. Nmr imagery. Nmr spectrometry; schizophrenia; Schizophrenia - pathology; Schizophrenia - physiopathology; Temporal Lobe - pathology; Temporal Lobe - physiology; Psychosis; Mood disorder; Nervous system diseases; LDDMM; planum temporale; Radiodiagnosis; cortical thickness; Schizophrenia; Bipolar disorder; Gaussian random field; psychotic bipolar disorder; Laplace-Beltrami operator
• ISSN: 1065-9471; 1097-0193; 1097-0193
• DOI: 10.1002/hbm.20444

In neuroimaging studies, spatial normalization and multivariate testing are central problems in characterizing group variation of functions (e.g., cortical thickness, curvature, functional response) in an atlas coordinate system across clinical populations. We present a region‐of‐interest (ROI)‐based analysis framework for detecting such a group variation. This framework includes two main techniques: ROI‐based registration via large deformation diffeomorphic metric surface mapping and a multivariate testing using a Gaussian random field (GRF) model on the cortical surface constructed by the eigenfunctions of the Laplace–Beltramioperator. We compared our GRF statistical model with a pointwise hypothesis testing approach, whose P‐value is corrected using false discovery rate or random field theory at several smoothness scales. As an illustration, we applied this framework to a clinical study of the cortical thickness of the left planum temporale (PT) in subjects with psychotic bipolar disorder, schizophrenia, and healthy comparison controls. Our results show that the anterior portion of the left PT is thinner in the psychotic bipolar and schizophrenic groups than in the healthy control group, and the posterior portion of the left PT shows the reversal finding. Moreover, there may be a greater thickness variation in the left PT in psychotic bipolar patients when compared with that in schizophrenic patients. Hum Brain Mapp, 2008. © 2007 Wiley‐Liss, Inc.