Benzodiazepine intoxication treated with flumazenil (Anexate, RO 15-1788)

The efficacy and safety of flumazenil were assessed in comparison to placebo in a double-blind randomised study of 31 adults intoxicated with benzodiazepines. The criteria of efficacy were the degree of sedation, and orientation in time and space. Patients who received flumazenil awoke within minute...

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Bibliographic Details
Published inAnaesthesia Vol. 43; no. 4; p. 274
Main Authors Knudsen, L, Lonka, L, Sørensen, B H, Kirkegaard, L, Jensen, O V, Jensen, S
Format Journal Article
LanguageEnglish
Published England 01.04.1988
Subjects
Adolescent
Adult
Aged
Benzodiazepines - metabolism
Benzodiazepines - poisoning
Coma - chemically induced
Coma - drug therapy
Drug Evaluation
Female
Flumazenil - therapeutic use
Humans
Male
Middle Aged
Orientation - drug effects
Substance-Related Disorders
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Summary:The efficacy and safety of flumazenil were assessed in comparison to placebo in a double-blind randomised study of 31 adults intoxicated with benzodiazepines. The criteria of efficacy were the degree of sedation, and orientation in time and space. Patients who received flumazenil awoke within minutes but central depression returned partly one hour later, which reflects the short elimination half-life of the drug. Side effects were few and the results indicate that flumazenil is effective in the primary management of benzodiazepine overdose and in states where benzodiazepines have been taken with other drugs.
ISSN:0003-2409
DOI:10.1111/j.1365-2044.1988.tb08971.x