Could lncRNAs be the Missing Links in Control of Mesenchymal Stem Cell Differentiation?

Long suspected, recently recognized, and increasingly studied, non protein‐coding RNAs (ncRNAs) are emerging as key drivers of biological control and pathology. Since their discovery in 1993, microRNAs (miRNAs) have been the subject of intense research focus and investigations have revealed striking...

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Published inJournal of cellular physiology Vol. 230; no. 3; pp. 526 - 534
Main Authors Tye, Coralee E., Gordon, Jonathan A.R., Martin-Buley, Lori A., Stein, Janet L., Lian, Jane B., Stein, Gary S.
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.03.2015
Wiley Subscription Services, Inc
Subjects
Adipocytes - cytology
Adipocytes - metabolism
Biological control
Cell differentiation
Cell Differentiation - genetics
Chondrocytes - cytology
Chondrocytes - metabolism
Humans
Mesenchymal Stromal Cells - cytology
MicroRNAs - genetics
Myoblasts - cytology
Myoblasts - metabolism
Osteoblasts - cytology
Osteoblasts - metabolism
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Stem cells
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Summary:Long suspected, recently recognized, and increasingly studied, non protein‐coding RNAs (ncRNAs) are emerging as key drivers of biological control and pathology. Since their discovery in 1993, microRNAs (miRNAs) have been the subject of intense research focus and investigations have revealed striking findings, establishing that these molecules can exert a substantial level of biological control in numerous tissues. More recently, long ncRNAs (lncRNAs), the lesser‐studied siblings of miRNA, have been suggested to have a similar robust role in developmental and adult tissue regulation. Mesenchymal stem cells (MSCs) are an important source of multipotent cells for normal and therapeutic tissue repair. Much is known about the critical role of miRNAs in biogenesis and differentiation of MSCs however; recent studies have suggested lncRNAs may play an equally important role in the regulation of these cells. Here we highlight the role of lncRNAs in the regulation of mesenchymal stem cell lineages including adipocytes, chondrocytes, myoblasts, and osteoblasts. In addition, the potential for these noncoding RNAs to be used as biomarkers for disease or therapeutic targets is also discussed. J. Cell. Physiol. 230: 526–534, 2015. © 2014 Wiley Periodicals, Inc., A Wiley Company
Bibliography:ark:/67375/WNG-QZ59598X-J
istex:AFF6E86E5B2EFBCEDCB89148DF6745C8ADBEC25D
NIH - No. R01AR039588; No. R37DE012528; No. P01AR048818
ArticleID:JCP24834
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SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
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ISSN:0021-9541
1097-4652
1097-4652
DOI:10.1002/jcp.24834