The cerebral tremor circuit in a patient with Holmes tremor
The cerebral network associated with Holmes tremor has never been determined directly. A previous study reported a brain network that is functionally connected, in healthy individuals, to different lesions that cause Holmes tremor (lesion connectome). We report a 71‐year‐old man with severe left‐sid...
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| Published in | Annals of clinical and translational neurology Vol. 7; no. 8; pp. 1453 - 1458 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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United States
John Wiley & Sons, Inc
01.08.2020
John Wiley and Sons Inc Wiley |
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| Abstract | The cerebral network associated with Holmes tremor has never been determined directly. A previous study reported a brain network that is functionally connected, in healthy individuals, to different lesions that cause Holmes tremor (lesion connectome). We report a 71‐year‐old man with severe left‐sided tremor caused by a microbleed near the right red nucleus. Using accelerometry‐fMRI, we show tremor‐related activity in contralateral sensorimotor cortex and cerebellar vermis. This network was distinct from, but functionally coupled to, the Holmes lesion connectome. We propose that Holmes tremor involves three distinct cerebral mechanisms: a structural lesion, an intermediate lesion connectome, and symptom‐related activity. |
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| AbstractList | The cerebral network associated with Holmes tremor has never been determined directly. A previous study reported a brain network that is functionally connected, in healthy individuals, to different lesions that cause Holmes tremor (lesion connectome). We report a 71‐year‐old man with severe left‐sided tremor caused by a microbleed near the right red nucleus. Using accelerometry‐fMRI, we show tremor‐related activity in contralateral sensorimotor cortex and cerebellar vermis. This network was distinct from, but functionally coupled to, the Holmes lesion connectome. We propose that Holmes tremor involves three distinct cerebral mechanisms: a structural lesion, an intermediate lesion connectome, and symptom‐related activity. Abstract The cerebral network associated with Holmes tremor has never been determined directly. A previous study reported a brain network that is functionally connected, in healthy individuals, to different lesions that cause Holmes tremor (lesion connectome). We report a 71‐year‐old man with severe left‐sided tremor caused by a microbleed near the right red nucleus. Using accelerometry‐fMRI, we show tremor‐related activity in contralateral sensorimotor cortex and cerebellar vermis. This network was distinct from, but functionally coupled to, the Holmes lesion connectome. We propose that Holmes tremor involves three distinct cerebral mechanisms: a structural lesion, an intermediate lesion connectome, and symptom‐related activity. Abstract The cerebral network associated with Holmes tremor has never been determined directly. A previous study reported a brain network that is functionally connected, in healthy individuals, to different lesions that cause Holmes tremor (lesion connectome). We report a 71‐year‐old man with severe left‐sided tremor caused by a microbleed near the right red nucleus. Using accelerometry‐fMRI, we show tremor‐related activity in contralateral sensorimotor cortex and cerebellar vermis. This network was distinct from, but functionally coupled to, the Holmes lesion connectome. We propose that Holmes tremor involves three distinct cerebral mechanisms: a structural lesion, an intermediate lesion connectome, and symptom‐related activity. |
| Author | Munckhof, Pepijn Nieuwhof, Freek Bie, Rob M.A. Praamstra, Peter Helmich, Rick C. |
| AuthorAffiliation | 2 Department of Neurology Amsterdam UMC ‐ Locatie AMC Amsterdam Neuroscience Amsterdam The Netherlands 4 Department of Neurology Center of Expertise for Parkinson & Movement Disorders Donders Institute for Brain, Cognition and Behaviour Radboud University Medical Centre Nijmegen The Netherlands 3 Department of Neurosurgery Amsterdam UMC ‐ Locatie AMC University of Amsterdam Amsterdam The Netherlands 1 Centre for Cognitive Neuroimaging Donders Institute for Brain, Cognition and Behaviour Radboud University Nijmegen The Netherlands |
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| Cites_doi | 10.1002/ana.25618 10.1093/brain/awv228 10.1002/mds.27121 10.1523/JNEUROSCI.3634-15.2016 10.1093/brain/awy292 10.1016/j.nicl.2015.12.011 10.1093/brain/awz085 10.1002/mds.22059 10.1016/j.neuroimage.2006.05.056 10.1002/ana.22361 10.1093/brain/awz261 10.1016/j.neuroimage.2013.08.048 10.1097/WCO.0000000000000582 10.1038/s41593-019-0436-x 10.1073/pnas.1602413113 10.1056/NEJMra1706158 |
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| Snippet | The cerebral network associated with Holmes tremor has never been determined directly. A previous study reported a brain network that is functionally... Abstract The cerebral network associated with Holmes tremor has never been determined directly. A previous study reported a brain network that is functionally... Abstract The cerebral network associated with Holmes tremor has never been determined directly. A previous study reported a brain network that is functionally... |
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| SubjectTerms | Case Study Dopamine Posture Tremor (Muscular contraction) |
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| Title | The cerebral tremor circuit in a patient with Holmes tremor |
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