The cerebral tremor circuit in a patient with Holmes tremor

The cerebral network associated with Holmes tremor has never been determined directly. A previous study reported a brain network that is functionally connected, in healthy individuals, to different lesions that cause Holmes tremor (lesion connectome). We report a 71‐year‐old man with severe left‐sid...

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Bibliographic Details
Published inAnnals of clinical and translational neurology Vol. 7; no. 8; pp. 1453 - 1458
Main Authors Nieuwhof, Freek, Bie, Rob M.A., Praamstra, Peter, Munckhof, Pepijn, Helmich, Rick C.
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.08.2020
John Wiley and Sons Inc
Wiley
Subjects
Case Study
Dopamine
Posture
Tremor (Muscular contraction)
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Summary:The cerebral network associated with Holmes tremor has never been determined directly. A previous study reported a brain network that is functionally connected, in healthy individuals, to different lesions that cause Holmes tremor (lesion connectome). We report a 71‐year‐old man with severe left‐sided tremor caused by a microbleed near the right red nucleus. Using accelerometry‐fMRI, we show tremor‐related activity in contralateral sensorimotor cortex and cerebellar vermis. This network was distinct from, but functionally coupled to, the Holmes lesion connectome. We propose that Holmes tremor involves three distinct cerebral mechanisms: a structural lesion, an intermediate lesion connectome, and symptom‐related activity.
ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.51143