Endomorphins have orexigenic and anxiolytic activities in mice

This study was designed to investigate the effects of endomorphin 1 and 2, recently identified mu-opioid receptor selective peptides, on food intake and anxiety in non-food-deprived mice. The intracerebroventricular (i.c.v.) injection of either endomorphin 1 or 2 (0.03-30 nmol) increased food intake...

Full description

Saved in:
Bibliographic Details
Published inNeuroreport Vol. 9; no. 10; p. 2265
Main Authors Asakawa, A, Inui, A, Momose, K, Ueno, N, Fujino, M A, Kasuga, M
Format Journal Article
LanguageEnglish
Published England 13.07.1998
Subjects
Animals
Anti-Anxiety Agents - pharmacology
Appetite Stimulants - pharmacology
Eating - drug effects
Injections, Intraventricular
Male
Mice
Oligopeptides - administration & dosage
Oligopeptides - pharmacology
Receptors, Opioid, mu - agonists
Stimulation, Chemical
Online AccessGet more information

Cover

More Information
Summary:This study was designed to investigate the effects of endomorphin 1 and 2, recently identified mu-opioid receptor selective peptides, on food intake and anxiety in non-food-deprived mice. The intracerebroventricular (i.c.v.) injection of either endomorphin 1 or 2 (0.03-30 nmol) increased food intake in a dose-related manner. A significant increase was observed 20 min after i.c.v. injection of endomorphin 1 or 2 and continued for 4 h. In the elevated plus maze test, the i.c.v. injection of endomorphin 1 (30 nmol) significantly decreased the normal preference for the closed arms. These results suggest that endomorphin produces orexigenic and anxiolytic effects, and that the mu-opioid receptor contributes to the regulation of feeding and anxiety in mice.
ISSN:0959-4965
DOI:10.1097/00001756-199807130-00022