Schwann cells apoptosis is induced by high glucose in diabetic peripheral neuropathy

• Published in: Life sciences (1973) Vol. 248; pp. 117459 - 9
• Main Authors: Liu, Yu-pu, Shao, Shui-jin, Guo, Hai-dong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.05.2020; Elsevier BV
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Animals; Apoptosis; Apoptosis - drug effects; Apoptosis - genetics; Autophagy; Autophagy - drug effects; Autophagy - genetics; beta catenin; beta Catenin - genetics; beta Catenin - metabolism; Diabetes; Diabetes mellitus; Diabetic Neuropathies - complications; Diabetic Neuropathies - genetics; Diabetic Neuropathies - metabolism; Diabetic Neuropathies - pathology; Diabetic peripheral neuropathy; Endoplasmic reticulum; endoplasmic reticulum stress; Endoplasmic Reticulum Stress - drug effects; Extracellular Signal-Regulated MAP Kinases - genetics; Extracellular Signal-Regulated MAP Kinases - metabolism; Gene Expression Regulation; Glucose; Glucose - metabolism; Glucose - pharmacology; High glucose; Humans; Hyperglycemia; Hyperglycemia - complications; Hyperglycemia - genetics; Hyperglycemia - metabolism; Hyperglycemia - pathology; Inflammation; Insulin; Insulin - metabolism; mitogen-activated protein kinase; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; Nitrification; Oxidative stress; Oxidative Stress - drug effects; Pathogenesis; patients; peripheral nervous system diseases; Peripheral neuropathy; Phagocytosis; phosphatidylinositol 3-kinase; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Schwann cells; Schwann Cells - drug effects; Schwann Cells - metabolism; Schwann Cells - pathology; Signal Transduction; Signaling pathway; Wnt protein; β-Catenin; Diabetic peripheral neuropathy; Signaling pathway; Schwann cells; Apoptosis; High glucose

Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus that affects approximately half of patients with diabetes. Current treatment regimens cannot treat DPN effectively. Schwann cells (SCs) are very sensitive to glucose concentration and insulin, and closely associated w...