Schwann cells apoptosis is induced by high glucose in diabetic peripheral neuropathy

• Published in: Life sciences (1973) Vol. 248; pp. 117459 - 9
• Main Authors: Liu, Yu-pu, Shao, Shui-jin, Guo, Hai-dong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.05.2020; Elsevier BV
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Animals; Apoptosis; Apoptosis - drug effects; Apoptosis - genetics; Autophagy; Autophagy - drug effects; Autophagy - genetics; beta catenin; beta Catenin - genetics; beta Catenin - metabolism; Diabetes; Diabetes mellitus; Diabetic Neuropathies - complications; Diabetic Neuropathies - genetics; Diabetic Neuropathies - metabolism; Diabetic Neuropathies - pathology; Diabetic peripheral neuropathy; Endoplasmic reticulum; endoplasmic reticulum stress; Endoplasmic Reticulum Stress - drug effects; Extracellular Signal-Regulated MAP Kinases - genetics; Extracellular Signal-Regulated MAP Kinases - metabolism; Gene Expression Regulation; Glucose; Glucose - metabolism; Glucose - pharmacology; High glucose; Humans; Hyperglycemia; Hyperglycemia - complications; Hyperglycemia - genetics; Hyperglycemia - metabolism; Hyperglycemia - pathology; Inflammation; Insulin; Insulin - metabolism; mitogen-activated protein kinase; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; Nitrification; Oxidative stress; Oxidative Stress - drug effects; Pathogenesis; patients; peripheral nervous system diseases; Peripheral neuropathy; Phagocytosis; phosphatidylinositol 3-kinase; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Schwann cells; Schwann Cells - drug effects; Schwann Cells - metabolism; Schwann Cells - pathology; Signal Transduction; Signaling pathway; Wnt protein; β-Catenin; Diabetic peripheral neuropathy; Signaling pathway; Schwann cells; Apoptosis; High glucose
• ISSN: 0024-3205; 1879-0631; 1879-0631
• DOI: 10.1016/j.lfs.2020.117459

Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus that affects approximately half of patients with diabetes. Current treatment regimens cannot treat DPN effectively. Schwann cells (SCs) are very sensitive to glucose concentration and insulin, and closely associated with the occurrence and development of type 1 diabetic mellitus (T1DM) and DPN. Apoptosis of SCs is induced by hyperglycemia and is involved in the pathogenesis of DPN. This review considers the pathological processes of SCs apoptosis under high glucose, which include the following: oxidative stress, inflammatory reactions, endoplasmic reticulum stress, autophagy, nitrification and signaling pathways (PI3K/AKT, ERK, PERK/Nrf2, and Wnt/β-catenin). The clarification of mechanisms underlying SCs apoptosis induced by high glucose will help us to understand and identify more effective strategies for the treatment of T1DM DPN. [Display omitted]