Schwann cells apoptosis is induced by high glucose in diabetic peripheral neuropathy

Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus that affects approximately half of patients with diabetes. Current treatment regimens cannot treat DPN effectively. Schwann cells (SCs) are very sensitive to glucose concentration and insulin, and closely associated w...

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Published inLife sciences (1973) Vol. 248; pp. 117459 - 9
Main Authors Liu, Yu-pu, Shao, Shui-jin, Guo, Hai-dong
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.05.2020
Elsevier BV
Subjects
1-Phosphatidylinositol 3-kinase
AKT protein
Animals
Apoptosis
Apoptosis - drug effects
Apoptosis - genetics
Autophagy
Autophagy - drug effects
Autophagy - genetics
beta catenin
beta Catenin - genetics
beta Catenin - metabolism
Diabetes
Diabetes mellitus
Diabetic Neuropathies - complications
Diabetic Neuropathies - genetics
Diabetic Neuropathies - metabolism
Diabetic Neuropathies - pathology
Diabetic peripheral neuropathy
Endoplasmic reticulum
endoplasmic reticulum stress
Endoplasmic Reticulum Stress - drug effects
Extracellular Signal-Regulated MAP Kinases - genetics
Extracellular Signal-Regulated MAP Kinases - metabolism
Gene Expression Regulation
Glucose
Glucose - metabolism
Glucose - pharmacology
High glucose
Humans
Hyperglycemia
Hyperglycemia - complications
Hyperglycemia - genetics
Hyperglycemia - metabolism
Hyperglycemia - pathology
Inflammation
Insulin
Insulin - metabolism
mitogen-activated protein kinase
NF-E2-Related Factor 2 - genetics
NF-E2-Related Factor 2 - metabolism
Nitrification
Oxidative stress
Oxidative Stress - drug effects
Pathogenesis
patients
peripheral nervous system diseases
Peripheral neuropathy
Phagocytosis
phosphatidylinositol 3-kinase
Phosphatidylinositol 3-Kinases - genetics
Phosphatidylinositol 3-Kinases - metabolism
Proto-Oncogene Proteins c-akt - genetics
Proto-Oncogene Proteins c-akt - metabolism
Schwann cells
Schwann Cells - drug effects
Schwann Cells - metabolism
Schwann Cells - pathology
Signal Transduction
Signaling pathway
Wnt protein
β-Catenin
Diabetic peripheral neuropathy
Signaling pathway
Schwann cells
Apoptosis
High glucose
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Abstract Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus that affects approximately half of patients with diabetes. Current treatment regimens cannot treat DPN effectively. Schwann cells (SCs) are very sensitive to glucose concentration and insulin, and closely associated with the occurrence and development of type 1 diabetic mellitus (T1DM) and DPN. Apoptosis of SCs is induced by hyperglycemia and is involved in the pathogenesis of DPN. This review considers the pathological processes of SCs apoptosis under high glucose, which include the following: oxidative stress, inflammatory reactions, endoplasmic reticulum stress, autophagy, nitrification and signaling pathways (PI3K/AKT, ERK, PERK/Nrf2, and Wnt/β-catenin). The clarification of mechanisms underlying SCs apoptosis induced by high glucose will help us to understand and identify more effective strategies for the treatment of T1DM DPN. [Display omitted]
AbstractList Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus that affects approximately half of patients with diabetes. Current treatment regimens cannot treat DPN effectively. Schwann cells (SCs) are very sensitive to glucose concentration and insulin, and closely associated with the occurrence and development of type 1 diabetic mellitus (T1DM) and DPN. Apoptosis of SCs is induced by hyperglycemia and is involved in the pathogenesis of DPN. This review considers the pathological processes of SCs apoptosis under high glucose, which include the following: oxidative stress, inflammatory reactions, endoplasmic reticulum stress, autophagy, nitrification and signaling pathways (PI3K/AKT, ERK, PERK/Nrf2, and Wnt/β-catenin). The clarification of mechanisms underlying SCs apoptosis induced by high glucose will help us to understand and identify more effective strategies for the treatment of T1DM DPN.
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus that affects approximately half of patients with diabetes. Current treatment regimens cannot treat DPN effectively. Schwann cells (SCs) are very sensitive to glucose concentration and insulin, and closely associated with the occurrence and development of type 1 diabetic mellitus (T1DM) and DPN. Apoptosis of SCs is induced by hyperglycemia and is involved in the pathogenesis of DPN. This review considers the pathological processes of SCs apoptosis under high glucose, which include the following: oxidative stress, inflammatory reactions, endoplasmic reticulum stress, autophagy, nitrification and signaling pathways (PI3K/AKT, ERK, PERK/Nrf2, and Wnt/β-catenin). The clarification of mechanisms underlying SCs apoptosis induced by high glucose will help us to understand and identify more effective strategies for the treatment of T1DM DPN. [Display omitted]
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus that affects approximately half of patients with diabetes. Current treatment regimens cannot treat DPN effectively. Schwann cells (SCs) are very sensitive to glucose concentration and insulin, and closely associated with the occurrence and development of type 1 diabetic mellitus (T1DM) and DPN. Apoptosis of SCs is induced by hyperglycemia and is involved in the pathogenesis of DPN. This review considers the pathological processes of SCs apoptosis under high glucose, which include the following: oxidative stress, inflammatory reactions, endoplasmic reticulum stress, autophagy, nitrification and signaling pathways (PI3K/AKT, ERK, PERK/Nrf2, and Wnt/β-catenin). The clarification of mechanisms underlying SCs apoptosis induced by high glucose will help us to understand and identify more effective strategies for the treatment of T1DM DPN.Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus that affects approximately half of patients with diabetes. Current treatment regimens cannot treat DPN effectively. Schwann cells (SCs) are very sensitive to glucose concentration and insulin, and closely associated with the occurrence and development of type 1 diabetic mellitus (T1DM) and DPN. Apoptosis of SCs is induced by hyperglycemia and is involved in the pathogenesis of DPN. This review considers the pathological processes of SCs apoptosis under high glucose, which include the following: oxidative stress, inflammatory reactions, endoplasmic reticulum stress, autophagy, nitrification and signaling pathways (PI3K/AKT, ERK, PERK/Nrf2, and Wnt/β-catenin). The clarification of mechanisms underlying SCs apoptosis induced by high glucose will help us to understand and identify more effective strategies for the treatment of T1DM DPN.
ArticleNumber 117459
Author Shao, Shui-jin
Guo, Hai-dong
Liu, Yu-pu
Author_xml – sequence: 1
  givenname: Yu-pu
  surname: Liu
  fullname: Liu, Yu-pu
– sequence: 2
  givenname: Shui-jin
  surname: Shao
  fullname: Shao, Shui-jin
  email: shaoshuijin@163.com
– sequence: 3
  givenname: Hai-dong
  surname: Guo
  fullname: Guo, Hai-dong
  email: hdguo8@hotmail.com
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32092332$$D View this record in MEDLINE/PubMed
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IsPeerReviewed true
IsScholarly true
Keywords Diabetic peripheral neuropathy
Signaling pathway
Schwann cells
Apoptosis
High glucose
Language English
License Copyright © 2020 Elsevier Inc. All rights reserved.
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Snippet Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus that affects approximately half of patients with diabetes. Current treatment...
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SubjectTerms 1-Phosphatidylinositol 3-kinase
AKT protein
Animals
Apoptosis
Apoptosis - drug effects
Apoptosis - genetics
Autophagy
Autophagy - drug effects
Autophagy - genetics
beta catenin
beta Catenin - genetics
beta Catenin - metabolism
Diabetes
Diabetes mellitus
Diabetic Neuropathies - complications
Diabetic Neuropathies - genetics
Diabetic Neuropathies - metabolism
Diabetic Neuropathies - pathology
Diabetic peripheral neuropathy
Endoplasmic reticulum
endoplasmic reticulum stress
Endoplasmic Reticulum Stress - drug effects
Extracellular Signal-Regulated MAP Kinases - genetics
Extracellular Signal-Regulated MAP Kinases - metabolism
Gene Expression Regulation
Glucose
Glucose - metabolism
Glucose - pharmacology
High glucose
Humans
Hyperglycemia
Hyperglycemia - complications
Hyperglycemia - genetics
Hyperglycemia - metabolism
Hyperglycemia - pathology
Inflammation
Insulin
Insulin - metabolism
mitogen-activated protein kinase
NF-E2-Related Factor 2 - genetics
NF-E2-Related Factor 2 - metabolism
Nitrification
Oxidative stress
Oxidative Stress - drug effects
Pathogenesis
patients
peripheral nervous system diseases
Peripheral neuropathy
Phagocytosis
phosphatidylinositol 3-kinase
Phosphatidylinositol 3-Kinases - genetics
Phosphatidylinositol 3-Kinases - metabolism
Proto-Oncogene Proteins c-akt - genetics
Proto-Oncogene Proteins c-akt - metabolism
Schwann cells
Schwann Cells - drug effects
Schwann Cells - metabolism
Schwann Cells - pathology
Signal Transduction
Signaling pathway
Wnt protein
β-Catenin
Title Schwann cells apoptosis is induced by high glucose in diabetic peripheral neuropathy
URI https://dx.doi.org/10.1016/j.lfs.2020.117459
https://www.ncbi.nlm.nih.gov/pubmed/32092332
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https://www.proquest.com/docview/2400481863
Volume 248
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