Low-molecular-weight-chitosan ameliorates cadmium-induced toxicity in the freshwater crab, Sinopotamon yangtsekiense
Cadmium (Cd) has been shown to induce oxidative stress. Low-molecular-weight-chitosan (LMWC) has been demonstrated to exhibit potent antioxidant effects. We investigated the regulation role in Cd 2+-induced oxidative damage in the hepatopancreas of the freshwater crab Sinopotamon yangtsekiense and t...
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Published in | Ecotoxicology and environmental safety Vol. 74; no. 5; pp. 1164 - 1170 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
San Diego, CA
Elsevier Inc
01.07.2011
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Cadmium (Cd) has been shown to induce oxidative stress. Low-molecular-weight-chitosan (LMWC) has been demonstrated to exhibit potent antioxidant effects. We investigated the regulation role in Cd
2+-induced oxidative damage in the hepatopancreas of the freshwater crab
Sinopotamon yangtsekiense and the protective effect of LMWC. The results showed that Cd
2+ significantly increased the hepatopancreatic metallothionein (MT) mRNA levels and protein kinase C (PKC) activity while decreasing the activities of Na
+,K
+-ATPase and Ca
2+-ATPase in crabs relative to the control group. Co-treatment with LMWC suppressed the levels of MT and PKC but raised the activities of Na
+,K+-ATPase and Ca
2+-ATPase in hepatopancreatic tissues compared with the crabs exposed to Cd
2+ alone. We postulate that LMWC may exert its protective effect through regulating the expressions of MT, PKC, Na
+,K
+-ATPase and Ca
2+-ATPase, thereby enhancing antioxidant defense. These observations suggest that LMWC may be beneficial because of its ability to alleviate the Cd
2+-induced damages to the crabs. |
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Bibliography: | http://dx.doi.org/10.1016/j.ecoenv.2011.02.018 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0147-6513 1090-2414 |
DOI: | 10.1016/j.ecoenv.2011.02.018 |