Solvent-free imino-aldol three-component couplings on a conveniently-prepared and reusable phosphoric acid-silica gel support

A new solvent-free procedure for the synthesis of beta-amino carbonyl compounds in generally moderate to excellent yields has been developed. Three-component Mannich-type couplings between aldehydes (aromatic, aliphatic, alicyclic, and heterocyclic), aromatic amines and silyl enol equivalents procee...

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Bibliographic Details
Published inChemistry letters Vol. 33; no. 10; pp. 1308 - 1309
Main Authors Lock, S, Miyoshi, N, Wada, M
Format Journal Article
LanguageEnglish
Published TOKYO Chemical Soc Japan 01.10.2004
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
EFFICIENT CATALYST
CONVERSION
BISMUTH TRICHLORIDE
WATER
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Summary:A new solvent-free procedure for the synthesis of beta-amino carbonyl compounds in generally moderate to excellent yields has been developed. Three-component Mannich-type couplings between aldehydes (aromatic, aliphatic, alicyclic, and heterocyclic), aromatic amines and silyl enol equivalents proceeded smoothly on a conveniently prepared and reusable phosphoric acid-silica gel solid support.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2004.1308