Solvent-free imino-aldol three-component couplings on a conveniently-prepared and reusable phosphoric acid-silica gel support
A new solvent-free procedure for the synthesis of beta-amino carbonyl compounds in generally moderate to excellent yields has been developed. Three-component Mannich-type couplings between aldehydes (aromatic, aliphatic, alicyclic, and heterocyclic), aromatic amines and silyl enol equivalents procee...
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Published in | Chemistry letters Vol. 33; no. 10; pp. 1308 - 1309 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
TOKYO
Chemical Soc Japan
01.10.2004
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Subjects | |
Online Access | Get more information |
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Summary: | A new solvent-free procedure for the synthesis of beta-amino carbonyl compounds in generally moderate to excellent yields has been developed. Three-component Mannich-type couplings between aldehydes (aromatic, aliphatic, alicyclic, and heterocyclic), aromatic amines and silyl enol equivalents proceeded smoothly on a conveniently prepared and reusable phosphoric acid-silica gel solid support. |
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ISSN: | 0366-7022 1348-0715 |
DOI: | 10.1246/cl.2004.1308 |