Plasma level of sICAM-1 is associated with the extent of white matter lesion among asymptomatic elderly subjects

Abstract Objective Inflammatory endothelial activation mediated by intercellular adhesion molecule-1 (ICAM-1) plays a role in the pathogenesis of large- and small-vessel disease. We explored the association between soluble ICAM-1 (sICAM-1) and white matter lesion (WML) as a manifestation of cerebral...

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Published inClinical neurology and neurosurgery Vol. 111; no. 10; pp. 847 - 851
Main Authors Han, Jing Hao, Wong, Ka Sing, Wang, Yan Yan, Fu, Jian Hui, Ding, Ding, Hong, Zhen
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.12.2009
Elsevier
Elsevier Limited
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Summary:Abstract Objective Inflammatory endothelial activation mediated by intercellular adhesion molecule-1 (ICAM-1) plays a role in the pathogenesis of large- and small-vessel disease. We explored the association between soluble ICAM-1 (sICAM-1) and white matter lesion (WML) as a manifestation of cerebral small-vessel disease. Methods One hundred and seventy-five elderly individuals aged ≥ 60 without neurological deficits were studied. Subcortical deep white matter hyperintensity (SDWMH) and periventricular hyperintensity (PVH) were rated separately. Lesions in each category were then divided into three groups (grade 0-I, grade II, grade III) according to the Fazekas scale. Results Plasma sICAM-1 levels were positively associated with grades of WML (for SDWMH: 297.4 ± 135.6 ng/mL in grade 0-I, 391.3 ± 145.5 ng/mL in grade II, and 450.2 ± 232.9 ng/mL in grade III, p < 0.001; for PVH: 282.5 ± 116.5 ng/mL in grade 0-I, 402.3 ± 160.4 ng/mL in grade II, and 428.1 ± 227.7 ng/mL in grade III, p < 0.001). Multivariate analysis showed higher sICAM-1 levels, age and hypertension were the independent risk factors associated with the presence and severity of WML. More than 4-fold increased risk of WML was observed in patients with the highest quartile of sICAM-1 (all WML OR = 4.694, 95% CI: 1.805–12.204; moderate WML OR = 4.618, 95% CI: 1.543–13.825; severe WML OR = 4.893, 95% CI: 1.236–19.368). Conclusion Increased plasma sICAM-1 suggests inflammatory process may be involved in the pathogenesis of WML.
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ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2009.08.018