Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer

• Published in: British journal of cancer Vol. 109; no. 7; pp. 1908 - 1913
• Main Authors: Uccella, S, Mariani, A, Wang, A H, Vierkant, R A, Cliby, W A, Robien, K, Anderson, K E, Cerhan, J R
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2013; Nature Publishing Group
• Subjects: 692/699/2743/393; 692/699/67/1517/1931; Aged; Aged, 80 and over; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Body Mass Index; Caffeine; Cancer Research; Coffee; Drug Resistance; Eating; Endometrial cancer; Endometrial Neoplasms - epidemiology; Epidemiology; Female; Female genital diseases; Food Preferences; Gynecology. Andrology. Obstetrics; Health sciences; Humans; Medical research; Medical sciences; Middle Aged; Molecular Medicine; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Obesity; Oncology; Postmenopause; Prospective Studies; Risk Factors; Short Communication; Surveys and Questionnaires; Tea; Tumors; Womens health; Xanthines - administration & dosage; United States > US; Iowa; tea; decaffeinated coffee; caffeine; methylxanthines; coffee; endometrial cancer; cola; Endometrium cancer; Psychotropic; Risk; Coffee; Respiratory analeptic; Cancerology; Dicotyledones; Angiospermae; Uterine diseases; Xanthine derivatives; Caffeine; Cola; Nutrition; CNS stimulant; Malignant tumor; Feeding; Female genital diseases; Tea; Diet; Sterculiaceae; Risk factor; Spermatophyta; Comparative study; Cancer
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/bjc.2013.540

Background: Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously. Methods: Prospective cohort of 23 356 postmenopausal women with 471 Type I and 71 Type II EC cases. Results: Type I EC was statistically significantly associated with caffeinated (relative risk (RR)=0.65 for 4+ cups per day vs ⩽1 cup per month: 95% confidence interval (CI): 0.47–0.89) but not decaffeinated (RR=0.76; 95% CI: 0.50–1.15) coffee intake; there were no associations with tea, cola or chocolate, or for Type II EC. The inverse association with caffeinated coffee intake was specific to women with a body mass index 30+ kg m −2 (RR=0.56; 95% CI: 0.36–0.89). Conclusion: Coffee may protect against Type I EC in obese postmenopausal women.