Mesenchymal stem cells increase skin graft survival time and up-regulate PD-L1 expression in splenocytes of mice

Highlights • MSCs administration can induce the prolongation of skin allograft acceptance in mice. • Increasing PD-L1 expression in splenocytes may be one of the mechanisms that MSCs use to inhibit immune responses. • MSCs administration cannot change the expression of IDO in splenocytes. • MSCs inc...

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Published inImmunology letters Vol. 182; pp. 39 - 49
Main Authors Moravej, Ali, Geramizadeh, Bita, Azarpira, Negar, Zarnani, Amir-Hassan, Yaghobi, Ramin, Kalani, Mehdi, Khosravi, Maryam, Kouhpayeh, Amin, Karimi, Mohammad-Hossein
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.02.2017
Subjects
Allergy and Immunology
Animals
B7-H1 Antigen - genetics
Biomarkers
Cytokines - blood
Cytokines - genetics
Cytokines - metabolism
Gene Expression Regulation
Graft Survival
IDO
Immunomodulation
Immunophenotyping
Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism
Mesenchymal Stem Cell Transplantation
Mesenchymal Stromal Cells - metabolism
Mice
MSCs
PD-L1
Skin Transplantation
Spleen - cytology
Spleen - immunology
Spleen - metabolism
Transplantation
PD-L1
MSCs
Transplantation
Immunomodulation
IDO
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Summary:Highlights • MSCs administration can induce the prolongation of skin allograft acceptance in mice. • Increasing PD-L1 expression in splenocytes may be one of the mechanisms that MSCs use to inhibit immune responses. • MSCs administration cannot change the expression of IDO in splenocytes. • MSCs increase the secretion of IL-10 as well as inhibition of IL-2 and IFN-γ in serum.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2017.01.005