Distribution and Spread of Colonic Lesions in Shigellosis: A Colonoscopic Study

• Published in: The Journal of infectious diseases Vol. 150; no. 6; pp. 899 - 903
• Main Authors: Speelman, Peter, Kabir, Iqbal, Islam, Moyenul
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.12.1984; University of Chicago Press
• Subjects: Adult; Bacillary dysentery; Bacterial diseases; Bacterial diseases of the digestive system and abdomen; Biological and medical sciences; Biopsy; Colitis; Colon - pathology; Colonoscopy; Crypts; Dysentery; Dysentery, Bacillary - pathology; Edema; Gastroenterology. Liver. Pancreas. Abdomen; Human bacterial diseases; Humans; Infections; Infectious diseases; Inflammation; Lesions; Male; Medical sciences; Middle Aged; Original Articles; Shigella; Tropical medicine; Infection; Human; Bangladesh; Asia; Colonoscopy; Bacteriosis; Digestive diseases; Intestinal disease; Colon; Endoscopy; Shigellosis
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/150.6.899

In a study of the distribution and severity of colonic lesions in patients with shigellosis, colonoscopy was performed for 33 men with this disease. All 33 patients had inflammatory lesions in the rectosigmoid area; in 18(55%) the lesions extended to the splenic flexure, in 14 (42%) the disease extended to the distal transverse colon, in nine (27%) the area of involvement included the proximal transverse colon, and in five (15%) pancolitis was evident. In most patients lesions were continuous and diffuse, with the intensity of inflammation decreasing in a proximal direction. Biopsied samples from proximal lesions usually showed less severe inflammation than did those from more distal lesions. Aphthoid erosions, which have not previously been described in shigellosis, were observed in five patients. Proximal colitis was associated with diarrhea of four or more days' duration (P < .01, Fisher's exact test). These findings indicate that the rectosigmoid is the most frequently and most severely affected area of the colon in shigellosis and suggest that during the course of shigella infection, colonic lesions extend in a proximal direction.