Prospective study of alcohol consumption and metabolic syndrome

• Published in: The American journal of clinical nutrition Vol. 87; no. 5; pp. 1455 - 1463
• Main Authors: Baik, Inkyung, Shin, Chol
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Nutrition 01.05.2008; American Society for Clinical Nutrition; American Society for Clinical Nutrition, Inc
• Subjects: Adult; Aged; Alcohol Drinking - adverse effects; Alcohol use; alcoholic beverages; Alcoholic Beverages - adverse effects; Beer; beers; Biological and medical sciences; Cohort Studies; Correlation analysis; distilled spirits; drinking; Feeding. Feeding behavior; Female; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Humans; Korea - epidemiology; Koreans; Life Style; Male; men; metabolic syndrome; Metabolic Syndrome - epidemiology; Metabolic Syndrome - etiology; Metabolism; Middle Aged; Nutrition; Prospective Studies; questionnaires; risk assessment; Risk Factors; Studies; Surveys and Questionnaires; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Wine; wines; women; South Korea; Endocrinopathy; Human; Food intake; Metabolic diseases; Cardiovascular disease; Alcohol; Metabolic syndrome
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/87.5.1455

BACKGROUND: Alcohol consumption is related to the prevalent metabolic syndrome. Few studies have evaluated the effects of alcohol consumption on the development of metabolic syndrome. OBJECTIVE: We examined the association between alcohol consumption and incident metabolic syndrome. DESIGN: This was a prospective cohort study of 3833 male and female Koreans aged 40-69 y and free of the metabolic syndrome at baseline. Information on alcohol consumption was obtained periodically from interviewer-administered questionnaires. Incident cases of the metabolic syndrome were identified by biennial health examinations during 4 y of follow-up between 2003 and 2006. RESULTS: Compared with nondrinkers, the multivariate relative risk [RR (95% CI)] of the metabolic syndrome for very light drinkers consuming 0.1 to 5 g of alcohol per day (g/d) was 1.06 (0.71, 1.58), that for light drinkers consuming 5.1 to 15 g/d was 1.13 (0.69, 1.83), that for moderate drinkers consuming 15.1 to 30 g/d was 1.25 (0.75, 2.09), and that for heavy drinkers consuming >30 g/d was 1.63 (1.02, 2.62). All individual components of the metabolic syndrome were significantly associated with heavy drinking, particularly among heavy liquor drinkers. CONCLUSIONS: Heavy drinking, in particular among liquor drinkers, is associated with an increased risk of the metabolic syndrome by influencing its components. Further data are warranted to clarify the association between drinking minimal alcohol and the metabolic syndrome as well as the beverage-specific association for drinking beer or wine.