Natural products as modulators of retinoic acid receptor-related orphan receptors (RORs)

Covering: 1994 to 2020 Retinoic acid receptor-related orphan receptors (RORs) belong to a subfamily of the nuclear receptor superfamily and possess prominent roles in circadian rhythm, metabolism, inflammation, and cancer. They have been subject of research for over two decades and represent attract...

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Published inNatural product reports Vol. 38; no. 4; pp. 757 - 781
Main Authors Ladurner, Angela, Schwarz, Patrik F, Dirsch, Verena M
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 28.04.2021
Subjects
Circadian rhythms
Ligands
Metabolism
Modulators
Natural products
Orphan receptors
Receptors
Retinoic acid
Therapeutic targets
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Summary:Covering: 1994 to 2020 Retinoic acid receptor-related orphan receptors (RORs) belong to a subfamily of the nuclear receptor superfamily and possess prominent roles in circadian rhythm, metabolism, inflammation, and cancer. They have been subject of research for over two decades and represent attractive but challenging drug targets. Natural products were among the first identified ligands of RORs and continue to be of interest to this day. This review focuses on ligands and indirect modulators of RORs from natural sources and explores their roles in a therapeutic context. This review provides a comprehensive overview of natural product ligands of RAR-related orphan receptors (RORs).
Bibliography:Angela Ladurner studied Molecular Biology at the University of Vienna (Austria) and completed her doctoral studies on natural product research in the group of Verena Dirsch in 2013. She then worked as a postdoctoral scientist at the Medical University of Vienna and at the University of Vienna. Her research focused on the characterization of the mechanism of action of natural products.
Patrik Schwarz studied Pharmacy at the University of Vienna (Austria) where he graduated in 2019. Since March 2020, he works as a doctoral student at the Department of Pharmacognosy, University of Vienna, under the supervision of Verena Dirsch. He is interested in finding novel (natural) ligands of the nuclear receptor RORγ.
Verena Dirsch received her PhD from the University of Munich (1993) and then joined as postdoctoral fellow of the German Research Council the group of Koji Nakanishi at the Columbia University, New York. From 1995 to 2004 she held several academic positions in the group of Prof. Angelika Vollmar at the University of Munich. Since 2004, she is full professor at the University of Vienna and since 2006 head of the Department of Pharmacognosy. She also served as Vice-Dean at the Faculty of Life Sciences (2008-2014). Her main interest is to study the molecular mechanisms of natural products.
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ISSN:0265-0568
1460-4752
DOI:10.1039/d0np00047g