Efficacy and Safety of Botulinum Toxin Type A on Persistent Myofascial Pain: A Randomized Clinical Trial

• Published in: Toxins Vol. 12; no. 6; p. 395
• Main Authors: De la Torre Canales, Giancarlo, Alvarez-Pinzon, Natalia, Muñoz-Lora, Victor Ricardo Manuel, Vieira Peroni, Leonardo, Farias Gomes, Amanda, Sánchez-Ayala, Alfonso, Haiter-Neto, Francisco, Manfredini, Daniele, Rizzatti-Barbosa, Célia Marisa
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.06.2020; MDPI
• Subjects: Adult; Analgesics; Analgesics - administration & dosage; Analgesics - adverse effects; bone loss; Botulinum toxin; Botulinum toxin type A; Botulinum Toxins, Type A - administration & dosage; Botulinum Toxins, Type A - adverse effects; Brazil; chronic pain; Clinical trials; Dose-Response Relationship, Drug; Facial Pain - diagnosis; Facial Pain - drug therapy; Facial Pain - physiopathology; Female; Humans; Mandible; Mastication; Mastication - drug effects; Muscle contraction; Muscle function; Muscles; Muscular function; myofascial pain; Pain; Pain Measurement; Pain Threshold - drug effects; Rank tests; Safety; Saline solutions; Side effects; Studies; temporomandibular disorders; Thickness; Time Factors; Tomography; Toxins; Treatment Outcome; Ultrasonic imaging; Brazil; chronic pain; botulinum toxin type A; bone loss; myofascial pain; temporomandibular disorders

This study assessed the safety and efficacy of three different doses of BoNT-A for persistent myofascial pain (MFP). One hundred female subjects were randomly assigned into five groups (n = 20): oral appliance (OA), saline solution (SS) and three BoNT-A groups with different doses. Pain intensity an...