Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice

• Published in: Journal of veterinary science (Suwŏn-si, Korea) Vol. 11; no. 1; pp. 35 - 41
• Main Authors: Lee, S.H., Howon University, Gunsan, Republic of Korea, Heo, Y., Catholic University of Daegu, Gyungsan, Republic of Korea, Kim, Y.C., Keimyung University, Daegu, Republic of Korea
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한수의학회 01.03.2010; The Korean Society of Veterinary Science
• Subjects: Animals; atopic dermatitis; Behavior, Animal - drug effects; Chamomile - immunology; CITOQUINAS; CYTOKINE; CYTOKINES; Dermatitis, Atopic - drug therapy; Dermatitis, Atopic - immunology; Disease Models, Animal; German chamomile oil; Histamine - blood; IgE; Immunoglobulin E - blood; Immunoglobulin G - blood; Interleukin-4 - analysis; Male; Matricaria - immunology; MICE; Mice, Inbred BALB C; Original; Phytotherapy - methods; RATON; SOURIS; Specific Pathogen-Free Organisms; Th2 Cells - immunology; 수의학; cytokine; atopic dermatitis; mice; IgE; German chamomile oil
• ISSN: 1229-845X; 1976-555X
• DOI: 10.4142/jvs.2010.11.1.35

Historically, German chamomile (GC) oil has been used for treatment of skin disorders. BALB/c mice were sensitized twice a week with 100 μL of 1 % 2,4-dinitrochlorobenzene (DNCB) and challenged twice the following week with 100 μL, of 0.2% DNCB for atopic dermatitis induction. Thereafter, 3% GC oil was applied daily (70 μL, 6 times week) on the dorsal skin for 4 weeks. Saline or jojoba oil was used for the control mice. Blood was collected after second DNCB challenge, and at 2 and 4 weeks after initiating oil application. Serum IgE levels were significantly lowered in the GC oil application group at the end of the 4-week application period. The GC oil application for 4 weeks resulted in reduction in serum IgG1 level compared with that after 2-week application. The GC oil application group showed a significantly lower serum histamine level than the control group 2 weeks after oil application. Scratching frequency of the GC oil application group was significantly lower than either control groups. This study is to demonstrate GC oil's immunoregulatory potential for alleviating atopic dermatitis through influencing of Th2 cell activation.