CT features of focal organizing pneumonia: An analysis of consecutive histopathologically confirmed 45 cases

• Published in: European journal of radiology Vol. 83; no. 1; pp. 73 - 78
• Main Authors: Zhao, Feng, Yan, Sen-Xiang, Wang, Gao-Feng, Wang, Jin, Lu, Pu-Xuan, Chen, Bin, Yuan, Jing, Zhang, Shi-Zheng, Wang, Yi-Xiang J
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.01.2014
• Subjects: Adult; Aged; Cryptogenic Organizing Pneumonia - classification; Cryptogenic Organizing Pneumonia - diagnostic imaging; Cryptogenic Organizing Pneumonia - pathology; Diagnosis, Differential; Female; Humans; Infection; Lung; Male; Middle Aged; Observer Variation; Organizing pneumonia; Radiology; Reproducibility of Results; Sensitivity and Specificity; Tomography, X-Ray Computed - methods; Young Adult; Infection; CT; Organizing pneumonia; Lung
• ISSN: 0720-048X; 1872-7727
• DOI: 10.1016/j.ejrad.2013.04.017

Abstract Objective To study the CT characteristics of solitary focal organizing pneumonia (FOP). Materials and methods Chest CT of consecutive 45 patients (34 males and 11 females, median age: 56 years) with confirmed FOP were analyzed. The CT features between large FOP (>3 cm, n = 27) and small FOP (≤3 cm, n = 18) were compared. Results FOP lesions predominately located in peripheral lungs (86.7%), with the right lower lobe being most common lobe (44.4%). No lesion mainly located in the inner 1/3 of lungs. All large lesions were polygon in shape and had an irregular margin, while small lesions were more likely to be round or oval with an irregular or smooth border. Air bronchogram or small bubble-like lucency was present in majority of the lesions. 42.2% of lesions had incompact internal structure with inhomogeneous density besides air component. Most lesions were associated with a contraction or convergence of surrounding vessels; while no pulmonary vessel was interrupted abruptly by a small FOP lesion. Majority of large lesions had broad contact with the pleura, while only one patient had mild pleural effusion. Mild mediastinal lymph nodes enlargement was present in about 1/5 of the patients. Conclusion Compared with the known CT features of lung cancer, our results suggest differential diagnosis can often be made for large FOP, while small FOP may resemble lung cancer.