A precisely defined role for the tip link-associated protein TMIE in the mechanoelectrical transduction channel complex of inner ear hair cells

Inner ear hair cells transduce sound waves and acceleration. In the quest to identify the molecular machinery underlying mechanoelectrical transduction, Zhao et al. (2014) in this issue of Neuron reveal that the TMIE protein, essential for hearing, physically interacts with tip link protein protocad...

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Bibliographic Details
Published inNeuron (Cambridge, Mass.) Vol. 84; no. 5; pp. 889 - 891
Main Author Liedtke, Wolfgang
Format Journal Article
LanguageEnglish
Published United States Elsevier Limited 03.12.2014
Subjects
Animals
Cadherins - metabolism
Ears & hearing
Hair Cells, Auditory - physiology
Humans
Mechanotransduction, Cellular - genetics
Membrane Proteins - metabolism
Mutation
Physiology
Protein Precursors - metabolism
Proteins
Proteomics
Studies
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Summary:Inner ear hair cells transduce sound waves and acceleration. In the quest to identify the molecular machinery underlying mechanoelectrical transduction, Zhao et al. (2014) in this issue of Neuron reveal that the TMIE protein, essential for hearing, physically interacts with tip link protein protocadherin-15.
Bibliography:ObjectType-Article-2
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ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2014.11.015