Computational analysis suggests that alternative first exons are involved in tissue-specific transcription in rice (Oryza sativa)
Motivation: Transcription start site selection and alternative splicing greatly contribute to diversifying gene expression. Recent studies have revealed the existence of alternative first exons, but most have involved mammalian genes, and as yet the regulation of usage of alternative first exons has...
Saved in:
Published in | Bioinformatics Vol. 21; no. 9; pp. 1758 - 1763 |
---|---|
Main Authors | , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Oxford University Press
01.05.2005
Oxford Publishing Limited (England) |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Motivation: Transcription start site selection and alternative splicing greatly contribute to diversifying gene expression. Recent studies have revealed the existence of alternative first exons, but most have involved mammalian genes, and as yet the regulation of usage of alternative first exons has not been clarified, especially in plants. Results: We systematically identified putative alternative first exon transcripts in rice, verified the candidates using RT–PCR, and searched for the promoter elements that might regulate the alternative first exons. As a result, we detected a number of unreported alternative first exons, some of which are regulated in a tissue-specific manner. Contact: washy@sfc.keio.ac.jp Supplementary information: http://www.bioinfo.sfc.keio.ac.jp/research/intron |
---|---|
Bibliography: | To whom correspondence should be addressed. ark:/67375/HXZ-59GZPKBJ-S local:bti253 istex:F7F93175730D69AFFA576EC27592E77889C4321E ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 1367-4803 1460-2059 1367-4811 |
DOI: | 10.1093/bioinformatics/bti253 |