MicroRNA-199a-3p and microRNA-34a regulate apoptosis in human osteosarcoma cells

miRNAs (microRNAs) are small non-coding RNAs [18-25 nt (nucleotides)] that regulate gene expression mainly through affecting post-transcriptional modification. Osteosarcoma is an aggressive sarcoma of the bone characterized by a high level of genetic instability and recurrent DNA deletions and ampli...

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Bibliographic Details
Published inBioscience reports Vol. 34; no. 4; p. e00132
Main Authors Tian, Ye, Zhang, Ying-Ze, Chen, Wei
Format Journal Article
LanguageEnglish
Published England Portland Press Ltd 06.08.2014
Portland Press, Biochemical Society
Subjects
apoptosis
Apoptosis - genetics
Bone Neoplasms - genetics
Cell Line, Tumor
Gene Expression Regulation, Neoplastic - genetics
human osteosarcoma cells
Humans
microRNA-199a
microRNA-34a
MicroRNAs - genetics
Original Paper
Osteosarcoma - genetics
Signal Transduction - genetics
Tumor Suppressor Protein p53 - genetics
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Summary:miRNAs (microRNAs) are small non-coding RNAs [18-25 nt (nucleotides)] that regulate gene expression mainly through affecting post-transcriptional modification. Osteosarcoma is an aggressive sarcoma of the bone characterized by a high level of genetic instability and recurrent DNA deletions and amplifications. miRNAs play an important role in cancer cell growth and migration; however, the potential roles of miRNAs in osteosarcoma remain largely uncharacterized. In this paper, miR-199a and miR-34a were discussed the mechanisms of apoptosis using miRNA mimics in human osteosarcoma cells. The results demonstrated that miR-199a and miR-34a could induce the apoptosis of human osteosarcoma cells via p53 signalling pathway.
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ISSN:0144-8463
1573-4935
DOI:10.1042/BSR20140084