mGlu1 Receptor-Induced LTD of NMDA Receptor Transmission Selectively at Schaffer Collateral-CA1 Synapses Mediates Metaplasticity

Hippocampal CA1 pyramidal neurons receive inputs from entorhinal cortex directly via the temporoammonic (TA) pathway and indirectly via the Schaffer collateral (SC) pathway from CA3. NMDARs at synapses of both pathways are critical for the induction of synaptic plasticity, information processing, an...

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Published inThe Journal of neuroscience Vol. 34; no. 36; pp. 12223 - 12229
Main Authors Bhouri, Mehdi, Farrow, Paul A., Motee, Aneeta, Yan, Xu, Battaglia, Giuseppe, Di Menna, Luisa, Riozzi, Barbara, Nicoletti, Ferdinando, Fitzjohn, Stephen M., Bashir, Zafar I.
Format Journal Article
LanguageEnglish
Published United States Society for Neuroscience 03.09.2014
Subjects
Animals
Brief Communications
CA1 Region, Hippocampal - cytology
CA1 Region, Hippocampal - metabolism
CA1 Region, Hippocampal - physiology
Cells, Cultured
Excitatory Postsynaptic Potentials
Long-Term Potentiation
Long-Term Synaptic Depression
Male
Organ Specificity
Pyramidal Cells - metabolism
Pyramidal Cells - physiology
Rats
Rats, Wistar
Receptors, AMPA - metabolism
Receptors, N-Methyl-D-Aspartate - metabolism
Synapses - metabolism
Synapses - physiology
LTD
metaplasticity
NMDARs
Online AccessGet full text
ISSN0270-6474
1529-2401
1529-2401
DOI10.1523/JNEUROSCI.0753-14.2014

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Abstract Hippocampal CA1 pyramidal neurons receive inputs from entorhinal cortex directly via the temporoammonic (TA) pathway and indirectly via the Schaffer collateral (SC) pathway from CA3. NMDARs at synapses of both pathways are critical for the induction of synaptic plasticity, information processing, and learning and memory. We now demonstrate that, in the rat hippocampus, activity-dependent mGlu1 receptor-mediated LTD (mGlu1-LTD) of NMDAR-mediated transmission (EPSC NMDA ) at the SC-CA1 input prevents subsequent LTP of AMPAR-mediated transmission. In contrast, there was no activity-dependent mGlu1-LTD of EPSC NMDA at the TA-CA1 pathway, or effects on subsequent plasticity of AMPAR-mediated transmission. Therefore, the two major pathways delivering information to CA1 pyramidal neurons are subject to very different plasticity rules.
AbstractList Hippocampal CA1 pyramidal neurons receive inputs from entorhinal cortex directly via the temporoammonic (TA) pathway and indirectly via the Schaffer collateral (SC) pathway from CA3. NMDARs at synapses of both pathways are critical for the induction of synaptic plasticity, information processing, and learning and memory. We now demonstrate that, in the rat hippocampus, activity-dependent mGlu1 receptor-mediated LTD (mGlu1-LTD) of NMDAR-mediated transmission (EPSC(NMDA)) at the SC-CA1 input prevents subsequent LTP of AMPAR-mediated transmission. In contrast, there was no activity-dependent mGlu1-LTD of EPSC(NMDA) at the TA-CA1 pathway, or effects on subsequent plasticity of AMPAR-mediated transmission. Therefore, the two major pathways delivering information to CA1 pyramidal neurons are subject to very different plasticity rules.
Hippocampal CA1 pyramidal neurons receive inputs from entorhinal cortex directly via the temporoammonic (TA) pathway and indirectly via the Schaffer collateral (SC) pathway from CA3. NMDARs at synapses of both pathways are critical for the induction of synaptic plasticity, information processing, and learning and memory. We now demonstrate that, in the rat hippocampus, activity-dependent mGlu1 receptor-mediated LTD (mGlu1-LTD) of NMDAR-mediated transmission (EPSC NMDA ) at the SC-CA1 input prevents subsequent LTP of AMPAR-mediated transmission. In contrast, there was no activity-dependent mGlu1-LTD of EPSC NMDA at the TA-CA1 pathway, or effects on subsequent plasticity of AMPAR-mediated transmission. Therefore, the two major pathways delivering information to CA1 pyramidal neurons are subject to very different plasticity rules.
Hippocampal CA1 pyramidal neurons receive inputs from entorhinal cortex directly via the temporoammonic (TA) pathway and indirectly via the Schaffer collateral (SC) pathway from CA3. NMDARs at synapses of both pathways are critical for the induction of synaptic plasticity, information processing, and learning and memory. We now demonstrate that, in the rat hippocampus, activity-dependent mGlu1 receptor-mediated LTD (mGlu1-LTD) of NMDAR-mediated transmission (EPSC(NMDA)) at the SC-CA1 input prevents subsequent LTP of AMPAR-mediated transmission. In contrast, there was no activity-dependent mGlu1-LTD of EPSC(NMDA) at the TA-CA1 pathway, or effects on subsequent plasticity of AMPAR-mediated transmission. Therefore, the two major pathways delivering information to CA1 pyramidal neurons are subject to very different plasticity rules.Hippocampal CA1 pyramidal neurons receive inputs from entorhinal cortex directly via the temporoammonic (TA) pathway and indirectly via the Schaffer collateral (SC) pathway from CA3. NMDARs at synapses of both pathways are critical for the induction of synaptic plasticity, information processing, and learning and memory. We now demonstrate that, in the rat hippocampus, activity-dependent mGlu1 receptor-mediated LTD (mGlu1-LTD) of NMDAR-mediated transmission (EPSC(NMDA)) at the SC-CA1 input prevents subsequent LTP of AMPAR-mediated transmission. In contrast, there was no activity-dependent mGlu1-LTD of EPSC(NMDA) at the TA-CA1 pathway, or effects on subsequent plasticity of AMPAR-mediated transmission. Therefore, the two major pathways delivering information to CA1 pyramidal neurons are subject to very different plasticity rules.
Author Farrow, Paul A.
Yan, Xu
Bhouri, Mehdi
Di Menna, Luisa
Battaglia, Giuseppe
Nicoletti, Ferdinando
Bashir, Zafar I.
Motee, Aneeta
Riozzi, Barbara
Fitzjohn, Stephen M.
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Cites_doi 10.1016/j.tins.2013.03.007
10.1152/jn.00383.2005
10.1073/pnas.0608991104
10.1016/j.neuron.2007.11.024
10.1038/349156a0
10.1016/j.jneumeth.2006.12.018
10.1016/j.neuron.2011.02.006
10.1523/JNEUROSCI.4333-10.2010
10.1016/S0959-4388(00)00215-4
10.1126/science.1096615
10.1016/S0896-6273(03)00165-X
10.1016/j.neuropharm.2006.07.013
10.1523/JNEUROSCI.1697-04.2004
10.1016/j.neuropharm.2008.07.046
10.1002/hipo.20654
10.1113/jphysiol.1983.sp014478
10.1126/science.1128134
10.1073/pnas.89.10.4363
10.1152/jn.90643.2008
10.1038/416736a
10.1038/sj.bjp.0705744
10.1016/j.neuron.2010.05.015
10.1371/journal.pone.0010306
10.1016/j.neuron.2007.07.035
10.1113/jphysiol.2009.179382
10.1038/nn.3461
10.1016/j.conb.2012.01.007
10.1016/j.neuron.2007.11.023
10.1038/nrn2614
10.1111/j.1469-7793.1999.453ac.x
10.1126/science.1071089
10.1038/nrn2356
10.1016/S0896-6273(00)80102-6
10.1016/S0028-3908(00)00118-0
10.1038/319774a0
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Keywords LTD
metaplasticity
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P.A. Farrow's current address: Synaptic Signaling and Neurodegeneration, German Cancer Research Centre, Im Neuenheimer Feld, 69120 Heidelberg, Germany.
S.M.F. and Z.I.B. contributed equally as joint senior authors.
M. Bhouri's current address: School of Medicine, Department of Psychiatry and Behavioural Sciences, Lokey Stem Cell Building, Stanford University, Stanford, CA 94305.
X. Yan's current address: Neuroscience Center, PO Box 56 (Viikinkaari 4), FIN-00014 University of Helsinki, Helsinki, Finland.
Author contributions: M.B., P.A.F., S.M.F., and Z.I.B. designed research; M.B., P.A.F., A.M., X.Y., G.B., L.D.M., B.R., F.N., S.M.F., and Z.I.B. performed research; M.B., P.A.F., A.M., X.Y., G.B., L.D.M., B.R., F.N., S.M.F., and Z.I.B. analyzed data; F.N., S.M.F., and Z.I.B. wrote the paper.
M.B. and P.A.F. contributed equally as joint first authors.
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References 2023041304125379000_34.36.12223.1
2023041304125379000_34.36.12223.2
2023041304125379000_34.36.12223.15
2023041304125379000_34.36.12223.14
2023041304125379000_34.36.12223.13
2023041304125379000_34.36.12223.35
2023041304125379000_34.36.12223.12
2023041304125379000_34.36.12223.34
2023041304125379000_34.36.12223.11
2023041304125379000_34.36.12223.33
2023041304125379000_34.36.12223.10
2023041304125379000_34.36.12223.32
2023041304125379000_34.36.12223.31
2023041304125379000_34.36.12223.30
2023041304125379000_34.36.12223.19
2023041304125379000_34.36.12223.18
2023041304125379000_34.36.12223.17
2023041304125379000_34.36.12223.16
Collingridge (2023041304125379000_34.36.12223.9) 1983; 334
2023041304125379000_34.36.12223.26
2023041304125379000_34.36.12223.25
2023041304125379000_34.36.12223.7
2023041304125379000_34.36.12223.24
2023041304125379000_34.36.12223.8
2023041304125379000_34.36.12223.23
2023041304125379000_34.36.12223.5
2023041304125379000_34.36.12223.22
2023041304125379000_34.36.12223.6
2023041304125379000_34.36.12223.21
2023041304125379000_34.36.12223.3
2023041304125379000_34.36.12223.20
2023041304125379000_34.36.12223.4
2023041304125379000_34.36.12223.29
2023041304125379000_34.36.12223.28
2023041304125379000_34.36.12223.27
References_xml – ident: 2023041304125379000_34.36.12223.14
  doi: 10.1016/j.tins.2013.03.007
– ident: 2023041304125379000_34.36.12223.32
  doi: 10.1152/jn.00383.2005
– ident: 2023041304125379000_34.36.12223.18
  doi: 10.1073/pnas.0608991104
– ident: 2023041304125379000_34.36.12223.20
  doi: 10.1016/j.neuron.2007.11.024
– ident: 2023041304125379000_34.36.12223.5
  doi: 10.1038/349156a0
– ident: 2023041304125379000_34.36.12223.2
  doi: 10.1016/j.jneumeth.2006.12.018
– ident: 2023041304125379000_34.36.12223.7
  doi: 10.1016/j.neuron.2011.02.006
– ident: 2023041304125379000_34.36.12223.10
  doi: 10.1523/JNEUROSCI.4333-10.2010
– ident: 2023041304125379000_34.36.12223.11
  doi: 10.1016/S0959-4388(00)00215-4
– ident: 2023041304125379000_34.36.12223.22
  doi: 10.1126/science.1096615
– ident: 2023041304125379000_34.36.12223.26
  doi: 10.1016/S0896-6273(03)00165-X
– ident: 2023041304125379000_34.36.12223.4
  doi: 10.1016/j.neuropharm.2006.07.013
– ident: 2023041304125379000_34.36.12223.23
  doi: 10.1523/JNEUROSCI.1697-04.2004
– ident: 2023041304125379000_34.36.12223.35
  doi: 10.1016/j.neuropharm.2008.07.046
– ident: 2023041304125379000_34.36.12223.27
  doi: 10.1002/hipo.20654
– volume: 334
  start-page: 33
  year: 1983
  ident: 2023041304125379000_34.36.12223.9
  article-title: Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus
  publication-title: J Physiol
  doi: 10.1113/jphysiol.1983.sp014478
– ident: 2023041304125379000_34.36.12223.33
  doi: 10.1126/science.1128134
– ident: 2023041304125379000_34.36.12223.13
  doi: 10.1073/pnas.89.10.4363
– ident: 2023041304125379000_34.36.12223.17
  doi: 10.1152/jn.90643.2008
– ident: 2023041304125379000_34.36.12223.30
  doi: 10.1038/416736a
– ident: 2023041304125379000_34.36.12223.3
  doi: 10.1038/sj.bjp.0705744
– ident: 2023041304125379000_34.36.12223.21
  doi: 10.1016/j.neuron.2010.05.015
– ident: 2023041304125379000_34.36.12223.34
  doi: 10.1371/journal.pone.0010306
– ident: 2023041304125379000_34.36.12223.6
  doi: 10.1016/j.neuron.2007.07.035
– ident: 2023041304125379000_34.36.12223.29
  doi: 10.1113/jphysiol.2009.179382
– ident: 2023041304125379000_34.36.12223.16
  doi: 10.1038/nn.3461
– ident: 2023041304125379000_34.36.12223.15
  doi: 10.1016/j.conb.2012.01.007
– ident: 2023041304125379000_34.36.12223.28
  doi: 10.1016/j.neuron.2007.11.023
– ident: 2023041304125379000_34.36.12223.31
  doi: 10.1038/nrn2614
– ident: 2023041304125379000_34.36.12223.25
  doi: 10.1111/j.1469-7793.1999.453ac.x
– ident: 2023041304125379000_34.36.12223.8
  doi: 10.1126/science.1071089
– ident: 2023041304125379000_34.36.12223.1
  doi: 10.1038/nrn2356
– ident: 2023041304125379000_34.36.12223.12
  doi: 10.1016/S0896-6273(00)80102-6
– ident: 2023041304125379000_34.36.12223.19
  doi: 10.1016/S0028-3908(00)00118-0
– ident: 2023041304125379000_34.36.12223.24
  doi: 10.1038/319774a0
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Snippet Hippocampal CA1 pyramidal neurons receive inputs from entorhinal cortex directly via the temporoammonic (TA) pathway and indirectly via the Schaffer collateral...
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SubjectTerms Animals
Brief Communications
CA1 Region, Hippocampal - cytology
CA1 Region, Hippocampal - metabolism
CA1 Region, Hippocampal - physiology
Cells, Cultured
Excitatory Postsynaptic Potentials
Long-Term Potentiation
Long-Term Synaptic Depression
Male
Organ Specificity
Pyramidal Cells - metabolism
Pyramidal Cells - physiology
Rats
Rats, Wistar
Receptors, AMPA - metabolism
Receptors, N-Methyl-D-Aspartate - metabolism
Synapses - metabolism
Synapses - physiology
Title mGlu1 Receptor-Induced LTD of NMDA Receptor Transmission Selectively at Schaffer Collateral-CA1 Synapses Mediates Metaplasticity
URI https://www.ncbi.nlm.nih.gov/pubmed/25186764
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https://pubmed.ncbi.nlm.nih.gov/PMC4152615
Volume 34
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