mGlu1 Receptor-Induced LTD of NMDA Receptor Transmission Selectively at Schaffer Collateral-CA1 Synapses Mediates Metaplasticity

Hippocampal CA1 pyramidal neurons receive inputs from entorhinal cortex directly via the temporoammonic (TA) pathway and indirectly via the Schaffer collateral (SC) pathway from CA3. NMDARs at synapses of both pathways are critical for the induction of synaptic plasticity, information processing, an...

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Published inThe Journal of neuroscience Vol. 34; no. 36; pp. 12223 - 12229
Main Authors Bhouri, Mehdi, Farrow, Paul A., Motee, Aneeta, Yan, Xu, Battaglia, Giuseppe, Di Menna, Luisa, Riozzi, Barbara, Nicoletti, Ferdinando, Fitzjohn, Stephen M., Bashir, Zafar I.
Format Journal Article
LanguageEnglish
Published United States Society for Neuroscience 03.09.2014
Subjects
Animals
Brief Communications
CA1 Region, Hippocampal - cytology
CA1 Region, Hippocampal - metabolism
CA1 Region, Hippocampal - physiology
Cells, Cultured
Excitatory Postsynaptic Potentials
Long-Term Potentiation
Long-Term Synaptic Depression
Male
Organ Specificity
Pyramidal Cells - metabolism
Pyramidal Cells - physiology
Rats
Rats, Wistar
Receptors, AMPA - metabolism
Receptors, N-Methyl-D-Aspartate - metabolism
Synapses - metabolism
Synapses - physiology
LTD
metaplasticity
NMDARs
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ISSN0270-6474
1529-2401
1529-2401
DOI10.1523/JNEUROSCI.0753-14.2014

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Summary:Hippocampal CA1 pyramidal neurons receive inputs from entorhinal cortex directly via the temporoammonic (TA) pathway and indirectly via the Schaffer collateral (SC) pathway from CA3. NMDARs at synapses of both pathways are critical for the induction of synaptic plasticity, information processing, and learning and memory. We now demonstrate that, in the rat hippocampus, activity-dependent mGlu1 receptor-mediated LTD (mGlu1-LTD) of NMDAR-mediated transmission (EPSC NMDA ) at the SC-CA1 input prevents subsequent LTP of AMPAR-mediated transmission. In contrast, there was no activity-dependent mGlu1-LTD of EPSC NMDA at the TA-CA1 pathway, or effects on subsequent plasticity of AMPAR-mediated transmission. Therefore, the two major pathways delivering information to CA1 pyramidal neurons are subject to very different plasticity rules.
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P.A. Farrow's current address: Synaptic Signaling and Neurodegeneration, German Cancer Research Centre, Im Neuenheimer Feld, 69120 Heidelberg, Germany.
S.M.F. and Z.I.B. contributed equally as joint senior authors.
M. Bhouri's current address: School of Medicine, Department of Psychiatry and Behavioural Sciences, Lokey Stem Cell Building, Stanford University, Stanford, CA 94305.
X. Yan's current address: Neuroscience Center, PO Box 56 (Viikinkaari 4), FIN-00014 University of Helsinki, Helsinki, Finland.
Author contributions: M.B., P.A.F., S.M.F., and Z.I.B. designed research; M.B., P.A.F., A.M., X.Y., G.B., L.D.M., B.R., F.N., S.M.F., and Z.I.B. performed research; M.B., P.A.F., A.M., X.Y., G.B., L.D.M., B.R., F.N., S.M.F., and Z.I.B. analyzed data; F.N., S.M.F., and Z.I.B. wrote the paper.
M.B. and P.A.F. contributed equally as joint first authors.
ISSN:0270-6474
1529-2401
1529-2401
DOI:10.1523/JNEUROSCI.0753-14.2014