Short-term effect of multilevel surgery on adipokines and pro-inflammatory cytokines in patients with obstructive sleep apnea

• Published in: Acta oto-laryngologica Vol. 130; no. 12; pp. 1394 - 1398
• Main Authors: Eun, Young Gyu, Kim, Myung Gu, Kwon, Kee Hwan, Shin, Seung Youp, Cho, Joong Saeng, Kim, Sung Wan
• Format: Journal Article
• Language: English
• Published: Stockholm Informa Healthcare 01.12.2010; Taylor & Francis; Informa
• Subjects: Adipokines - blood; Adiponectin; Adiponectin - blood; Adult; Aged; Biological and medical sciences; Cytokines - blood; Electrosurgery; Female; Humans; IL-6; Inflammation Mediators - blood; Interleukin-6 - blood; leptin; Leptin - blood; Male; Medical sciences; Middle Aged; Otorhinolaryngology. Stomatology; Palate, Soft - surgery; Patient Satisfaction; Pharynx - surgery; Pneumology; Polysomnography; Reference Values; Respiratory system : syndromes and miscellaneous diseases; Sleep Apnea, Obstructive - blood; Sleep Apnea, Obstructive - surgery; TNF-α; Tongue - surgery; Tumor Necrosis Factor-alpha - blood; Uvula - surgery; Short term; Human; Nervous system diseases; Sleep apnea syndrome; Respiratory disease; Cytokine; ENT; leptin; IL-6; Adiponectin; Interleukin 6; Treatment; TNF-α; Surgery; Tumor necrosis factor α
• ISSN: 0001-6489; 1651-2251
• DOI: 10.3109/00016489.2010.495134

Abstract Conclusion: This study shows the possibility that multilevel surgery for obstructive sleep apnea (OSA) is helpful to improve the levels of pro-inflammatory cytokines and adipokines, which are related to complications of OSA. Objectives: The effects of multilevel surgery on adipokines and pro-inflammatory cytokines in patients with OSA were assessed. Methods: Fifty-one patients with OSA underwent uvulopalatopharyngoplasty and radiofrequency tongue base reduction. Body mass index (BMI), Epworth sleepiness scale (ESS) and subjective symptoms using visual analog scales were assessed at baseline and 4 weeks after treatment. Adiponectin, leptin, interleukin (IL)-6, and tumor necrosis factor (TNF)-α were measured with a LINCOplex Human Immunoassay at baseline and 4 weeks after surgical treatment. Results: Significant improvements in subjective symptoms and ESS were found at 4 weeks after multilevel surgery. No significant change in BMI was observed. Adiponectin level was significantly increased after surgical treatment. Postoperative leptin, IL-6, and TNF-α levels were significantly decreased. The percent changes of adiponectin, leptin, IL-6, and TNF-α after multilevel surgery were not significantly different among patients with mild, moderate, and severe OSA.