Dengue Infection - Recent Advances in Disease Pathogenesis in the Era of COVID-19

The dynamics of host-virus interactions, and impairment of the host’s immune surveillance by dengue virus (DENV) serotypes largely remain ambiguous. Several experimental and preclinical studies have demonstrated how the virus brings about severe disease by activating immune cells and other key eleme...

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Published inFrontiers in immunology Vol. 13; p. 889196
Main Authors Yong, Yean Kong, Wong, Won Fen, Vignesh, Ramachandran, Chattopadhyay, Indranil, Velu, Vijayakumar, Tan, Hong Yien, Zhang, Ying, Larsson, Marie, Shankar, Esaki M.
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 06.07.2022
Subjects
cytokine storm
dengue (DENV)
endothelial dysfunction
Immunology
inflammasome
pathogenesis
plasmablasts
COVID-19
pathogenesis
plasmablasts
cytokine storm
dengue (DENV)
inflammasome
antibody-dependent enhancement (ADE)
endothelial dysfunction
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Summary:The dynamics of host-virus interactions, and impairment of the host’s immune surveillance by dengue virus (DENV) serotypes largely remain ambiguous. Several experimental and preclinical studies have demonstrated how the virus brings about severe disease by activating immune cells and other key elements of the inflammatory cascade. Plasmablasts are activated during primary and secondary infections, and play a determinative role in severe dengue. The cross-reactivity of DENV immune responses with other flaviviruses can have implications both for cross-protection and severity of disease. The consequences of a cross-reactivity between DENV and anti-SARS-CoV-2 responses are highly relevant in endemic areas. Here, we review the latest progress in the understanding of dengue immunopathogenesis and provide suggestions to the development of target strategies against dengue.
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Edited by: Julie Olson, University of Minnesota Twin Cities, United States
Reviewed by: Leticia Cedillo-Barron, Centro de Investigaciones y Estudios Avanzados, Instituto Politécnico Nacional de México (CINVESTAV), Mexico; Ponpan Matangkasombut, Mahidol University, Thailand
These authors have contributed equally to this work
This article was submitted to Viral Immunology, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.889196