The biological function of the N6-Methyladenosine reader YTHDC2 and its role in diseases

• Published in: Journal of translational medicine Vol. 22; no. 1; pp. 490 - 13
• Main Authors: Wu, Xudong, Chen, Hui, Li, Kai, Zhang, Hong, Tan, Haoyu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.05.2024; BMC
• Subjects: Adenosine; Adenosine - analogs & derivatives; Adenosine - metabolism; Analysis; Animals; Biomarkers; Chemical properties; Disease; Health aspects; Humans; m6A; Methylation; N6-methyladenosine; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Post-translational modification; RNA Helicases; RNA-Binding Proteins - metabolism; Signal Transduction; Structure; Tumor biology; YTHDC2; China; Biomarkers; Tumor biology; m6A; N6-methyladenosine; YTHDC2
• ISSN: 1479-5876; 1479-5876
• DOI: 10.1186/s12967-024-05293-6

N6-methyladenosine (m6A) stands as the most prevalent modified form of RNA in eukaryotes, pivotal in various biological processes such as regulating RNA stability, translation, and transcription. All members within the YT521-B homology (YTH) gene family are categorized as m6A reading proteins, capable of identifying and binding m6A modifications on RNA, thereby regulating RNA metabolism and functioning across diverse physiological processes. YTH domain-containing 2 (YTHDC2), identified as the latest member of the YTH family, has only recently started to emerge for its biological function. Numerous studies have underscored the significance of YTHDC2 in human physiology, highlighting its involvement in both tumor progression and non-tumor diseases. Consequently, this review aims to further elucidate the pathological mechanisms of YTHDC2 by summarizing its functions and roles in tumors and other diseases, with a particular focus on its downstream molecular targets and signaling pathways.