The REV-ERB Nuclear Receptors: Timekeepers for the Core Clock Period and Metabolism

Abstract REV-ERB nuclear receptors are potent transcriptional repressors that play an important role in the core mammalian molecular clock and metabolism. Deletion of both REV-ERBα and its largely redundant isoform REV-ERBβ in a murine tissue–specific manner have shed light on their specific functio...

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Published inEndocrinology (Philadelphia) Vol. 164; no. 6; p. 1
Main Authors Adlanmerini, Marine, Lazar, Mitchell A
Format Journal Article
LanguageEnglish
Published US Oxford University Press 01.06.2023
Subjects
Animals
Circadian Clocks - genetics
Circadian Rhythm - genetics
Circadian rhythms
Endocrinology
Genes
Lipids
Mammals - metabolism
Metabolism
Mice
Mini-Review
Nuclear Receptor Subfamily 1, Group D, Member 1 - genetics
Nuclear Receptor Subfamily 1, Group D, Member 1 - metabolism
Nuclear receptors
Physiological aspects
Receptors
Receptors, Cytoplasmic and Nuclear - genetics
Repressors
Transcription factors
Vasoactive intestinal peptides
nuclear receptors
lipids
molecular clocks
desynchrony
REV-ERB
metabolism
circadian rhythms
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Summary:Abstract REV-ERB nuclear receptors are potent transcriptional repressors that play an important role in the core mammalian molecular clock and metabolism. Deletion of both REV-ERBα and its largely redundant isoform REV-ERBβ in a murine tissue–specific manner have shed light on their specific functions in clock mechanisms and circadian metabolism. This review highlights recent findings that establish REV-ERBs as crucial circadian timekeepers in a variety of tissues, regulating overlapping and distinct processes that maintain normal physiology and protect from metabolic dysfunction.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-2
ISSN:1945-7170
0013-7227
1945-7170
DOI:10.1210/endocr/bqad069