Hypothesis: Helicobacter pylori, urease, mucus, and gastric ulcer

Ammonia, released in the gastric mucosa by the action of Helicobacter pylori urease on transuded plasma urea, curtails the biosynthesis of mucus and/or causes the mucus to be disassembled at the mucosal surface. These changes facilitate colonisation by H pylori and may promote gastric ulcer formatio...

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Bibliographic Details
Published inThe Lancet (British edition) Vol. 335; no. 8683; p. 193
Main Authors Sidebotham, R L, Baron, J H
Format Journal Article
LanguageEnglish
Published England 27.01.1990
Subjects
Campylobacter - enzymology
Campylobacter Infections - complications
Gastric Mucosa - metabolism
Gastric Mucosa - pathology
Humans
Stomach Ulcer - etiology
Stomach Ulcer - metabolism
Stomach Ulcer - pathology
Urease - metabolism
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Summary:Ammonia, released in the gastric mucosa by the action of Helicobacter pylori urease on transuded plasma urea, curtails the biosynthesis of mucus and/or causes the mucus to be disassembled at the mucosal surface. These changes facilitate colonisation by H pylori and may promote gastric ulcer formation.
ISSN:0140-6736
DOI:10.1016/0140-6736(90)90279-E