Pickled meat consumption and colorectal cancer (CRC): a case-control study in Newfoundland and Labrador, Canada

• Published in: Cancer causes & control Vol. 21; no. 9; pp. 1513 - 1521
• Main Authors: Squires, Josh, Roebothan, Barbara, Buehler, Sharon, Sun, Zhuoyu, Cotterchio, Michelle, Younghusband, Ban, Dicks, Elizabeth, Mclaughlin, John R, Parfrey, Patrick S, Wang, Peizhong Peter
• Format: Journal Article
• Language: English
• Published: Dordrecht Dordrecht : Springer Netherlands 01.09.2010; Springer; Springer Netherlands; Springer Nature B.V
• Subjects: Adolescent; Adult; adverse effects; Age distribution; Aged; Alcohols; Biomedical and Life Sciences; Biomedicine; Cancer Research; Case control studies; Case-control; Colorectal cancer; colorectal neoplasms; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - etiology; Epidemiology; etiology; Exercise; Fat intake; Feeding Behavior; Female; Food consumption; Hematology; Humans; Logistic regression; Lung cancer; Male; Meat; Meat Products; Meat Products - adverse effects; Meats; Medical research; Middle Aged; Newfoundland & Labrador; Newfoundland and Labrador; Oncology; Original Paper; Pickled meat; Public Health; Questionnaires; red meat; Risk Factors; Surveys and Questionnaires; Womens health; Young Adult; Newfoundland & Labrador Canada; Canada; Newfoundland and Labrador; Canada, Newfoundland and Labrador; Pickled meat; Red meat; Newfoundland & Labrador; Colorectal cancer; Case–control
• ISSN: 0957-5243; 1573-7225; 1573-7225
• DOI: 10.1007/s10552-010-9580-z

Objective Although a large body of epidemiological research suggests that red meat intake increases the risk of colorectal cancer, little is known regarding how such an association varies across populations and types of red meat. The objective of this study was to assess whether an association exists between the intakes of total red meat and pickled red meat and the risk of colorectal cancer in study subjects residing in Newfoundland and Labrador. Methods This case-control study of 1,204 residents of Newfoundland and Labrador was part of a larger study on colorectal cancer. Personal history food frequency questionnaires were used to collect retrospective data from 518 individuals diagnosed with colorectal cancer and 686 controls. Intakes were ranked and divided into tertiles. Logistic regression was used to examine the possible association between meat intakes and colorectal cancer diagnosis while controlling for possible confounding factors. Results A positive, but non-statistically significant, association between total red meat intake and CRC was observed in this study. Pickled red meat consumption was found to be significantly associated with an increased risk of CRC (men, OR = 2.07, 95% CI 1.37-3.15; women, OR = 2.51, 95% CI 1.45-4.32), the odds ratios increasing with each tertile of consumption, suggesting a dose-response effect. Conclusion Intake of pickled red meat appears to increase the risk of colorectal cancer in Newfoundland and Labrador.