Caveolin proteins and estrogen signaling in the brain

Best described outside the nervous system, caveolins are structural proteins that form caveolae, functional microdomains at the plasma membrane that cluster related signaling molecules. Caveolin-associated proteins include G protein-coupled receptors and G proteins, receptor tyrosine kinases, as wel...

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Published inMolecular and cellular endocrinology Vol. 290; no. 1; pp. 8 - 13
Main Authors Luoma, Jessie I., Boulware, Marissa I., Mermelstein, Paul G.
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 13.08.2008
Subjects
Animals
Brain - metabolism
Caveolae
Caveolins - metabolism
Estradiol
Estrogen receptor
Estrogens - metabolism
Flotillin
Humans
Lordosis
Membrane receptor
mGluR
Protein Transport
Rapid actions
Receptors, Estrogen - metabolism
Signal Transduction
Estrogen receptor
Membrane receptor
Caveolae
Flotillin
Lordosis
Estradiol
mGluR
Rapid actions
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Summary:Best described outside the nervous system, caveolins are structural proteins that form caveolae, functional microdomains at the plasma membrane that cluster related signaling molecules. Caveolin-associated proteins include G protein-coupled receptors and G proteins, receptor tyrosine kinases, as well as protein kinases, ion channels and various other signaling enzymes. Not surprisingly, a wide array of biological disorders are thought to be rooted in caveolin dysfunction. In addition, caveolins traffic and cluster estrogen receptors to caveolae. Interactions between the estrogen receptors ERα and ERβ with caveolins appear critical in many non-neuronal cell types, e.g., disruption of normal function may underlie many forms of breast cancer. Recent findings suggest caveolins may also play an essential role in membrane estrogen receptor function in the nervous system. Not only are they expressed in neurons and glia, but different caveolin isoforms also appear necessary to generate distinct functional signaling complexes. With membrane estrogen receptors responsible for the efficient activation of a multitude of intracellular signaling pathways, which in turn influence a wide variety of nervous system functions, caveolin proteins are poised to act as the central coordinators of these processes.
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ISSN:0303-7207
1872-8057
DOI:10.1016/j.mce.2008.04.005