Specific increase of a mitochondrial RNA transcript in chronic ethanol-fed rats

• Published in: FEBS letters Vol. 304; no. 2; pp. 285 - 288
• Main Authors: Enriquez, J.A., Pérez-Martos, A., Fernández-Silva, P., López-Pérez, M.J., Montoya, J.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.06.1992; Elsevier
• Subjects: Alcoholism - physiopathology; Alcoholism and acute alcohol poisoning; Animals; Biological and medical sciences; DNA, Mitochondrial - metabolism; Ethanol; Isolated organelle; Male; Medical sciences; Mitochondria, Liver - drug effects; Mitochondria, Liver - metabolism; Mitochondrion; Poly A - metabolism; Rat liver; Rats; RNA - biosynthesis; RNA Processing, Post-Transcriptional; RNA synthesis; Toxicology; Mitochondrion; Isolated organelle; Ethanol; RNA synthesis; Rat liver; Animal model; Vertebrata; Mammalia; Rat; Transcription; Alcoholism; Rodentia; Mitochondrial DNA

An in vitro transcription system utilizing isolated mitochondria has been used to study the effect of chronic ethanol consumption on liver mitochondrial DNA transcription. The results obtained showed an overall increase of RNA synthesis and a dramatic accumulation of a discrete polyadenylated RNA sp...