Specific increase of a mitochondrial RNA transcript in chronic ethanol-fed rats

An in vitro transcription system utilizing isolated mitochondria has been used to study the effect of chronic ethanol consumption on liver mitochondrial DNA transcription. The results obtained showed an overall increase of RNA synthesis and a dramatic accumulation of a discrete polyadenylated RNA sp...

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Bibliographic Details
Published inFEBS letters Vol. 304; no. 2; pp. 285 - 288
Main Authors Enriquez, J.A., Pérez-Martos, A., Fernández-Silva, P., López-Pérez, M.J., Montoya, J.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 15.06.1992
Elsevier
Subjects
Alcoholism - physiopathology
Alcoholism and acute alcohol poisoning
Animals
Biological and medical sciences
DNA, Mitochondrial - metabolism
Ethanol
Isolated organelle
Male
Medical sciences
Mitochondria, Liver - drug effects
Mitochondria, Liver - metabolism
Mitochondrion
Poly A - metabolism
Rat liver
Rats
RNA - biosynthesis
RNA Processing, Post-Transcriptional
RNA synthesis
Toxicology
Mitochondrion
Isolated organelle
Ethanol
RNA synthesis
Rat liver
Animal model
Vertebrata
Mammalia
Rat
Transcription
Alcoholism
Rodentia
Mitochondrial DNA
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Summary:An in vitro transcription system utilizing isolated mitochondria has been used to study the effect of chronic ethanol consumption on liver mitochondrial DNA transcription. The results obtained showed an overall increase of RNA synthesis and a dramatic accumulation of a discrete polyadenylated RNA species. This effect is a consequence of the chronic ethanol consumption since these changes do not occur when isolated control mitochondria are incubated in the presence of ethanol.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(92)80639-X