Engineering Nanocarriers for siRNA Delivery

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 7; no. 7; pp. 841 - 856
• Main Authors: Tan, Shawn J., Kiatwuthinon, Pichamon, Roh, Young Hoon, Kahn, Jason S., Luo, Dan
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 04.04.2011; WILEY‐VCH Verlag
• Subjects: Genetic Therapy - methods; lipids; nanocarriers; nanoparticles; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Neoplasms - therapy; polymers; RNA Interference; RNA, Small Interfering - administration & dosage; RNA, Small Interfering - therapeutic use; siRNA delivery
• ISSN: 1613-6810; 1613-6829; 1613-6829
• DOI: 10.1002/smll.201001389

The discovery of RNA interference has revitalized the long ongoing pursuit of gene therapy for the treatment of diseases. Nevertheless, despite promising results from experimental studies, there remains a pressing need for the development of nanocarriers that are clinically‐relevant, biocompatible, efficient, and that can be tailored to specific disease targets. This review surveys the broad spectrum of nanomaterials and their functional add‐ons, and aims to provide a guide towards engineering nanocarriers for effective siRNA delivery. Nanomaterials for drug delivery: There is a pressing need for the development of nanocarriers that are clinically‐relevant, biocompatible, efficient, and that can be tailored to specific disease targets. This review surveys the broad spectrum of nanomaterials and their functional add‐ons, and aims to provide a guide towards engineering nanocarriers for effective siRNA delivery.