Detection and molecular characterization of adenoviruses in Korean children hospitalized with acute gastroenteritis

Human adenoviruses (HAdVs) are an important cause of acute gastroenteritis in children. However, few studies on the epidemiology or types of HAdVs associated with acute gastroenteritis have been conducted in Korea. Therefore, in the present study, the incidence of HAdV in 2064 stool samples from Kor...

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Bibliographic Details
Published inMicrobiology and immunology Vol. 56; no. 8; p. 523
Main Authors Lee, Jae In, Lee, Gyu-Cheol, Chung, Ju Young, Han, Tae Hee, Lee, Young Ki, Kim, Moo Sang, Lee, Chan Hee
Format Journal Article
LanguageEnglish
Published Australia 01.08.2012
Subjects
Adenovirus Infections, Human - epidemiology
Adenovirus Infections, Human - virology
Adenoviruses, Human - classification
Adenoviruses, Human - genetics
Adenoviruses, Human - isolation & purification
Asian Continental Ancestry Group
Child
Child, Preschool
DNA, Viral - genetics
Feces - virology
Gastroenteritis - epidemiology
Gastroenteritis - virology
Humans
Incidence
Molecular Epidemiology
Phylogeny
Polymerase Chain Reaction
Republic of Korea - epidemiology
Sequence Analysis, DNA
Republic of Korea
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Summary:Human adenoviruses (HAdVs) are an important cause of acute gastroenteritis in children. However, few studies on the epidemiology or types of HAdVs associated with acute gastroenteritis have been conducted in Korea. Therefore, in the present study, the incidence of HAdV in 2064 stool samples from Korean children hospitalized with acute gastroenteritis (2004-2006) was assessed and the types of viruses present determined. Polymerase chain reaction, sequencing, and phylogenic analyses revealed that 113 samples (5.5%) were HAdV-positive. While HAdVs were mainly detected during July to October, no seasonal difference between the enteric and non-enteric viruses in the incidence of HAdV was observed. HAdV-41 and HAdV-40 were found in 54 (47.8%) and 3 (2.6%) HAdV-positive samples, respectively. HAdV-3, HAdV-7, HAdV-2, HAdV-31, HAdV-4, and HAdV-37 were detected in 11 (9.7%), 5 (4.4%), 2 (1.7%), 2 (1.7%), 1 (0.8%), and 1 (0.8%) of sample(s), respectively. Thus, not only enteric, but also non-enteric, HAdVs may play an important role in acute gastroenteritis in Korean children.
ISSN:1348-0421
DOI:10.1111/j.1348-0421.2012.00469.x