[D-Ala2,D-Leu5]-enkephalin hydrochloride

The title compound, L-tyrosyl-D-alanyl-glycyl-L-phenyl-alanyl-D-leucine hydrochloride (C29H40N5O7+. Cl-), co-crystallizes with 2-butanone (C4H8O). The structure determination reveals a slightly distorted type I' beta-bend conformation stabilized by one intramolecular hydrogen bond. This conform...

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Bibliographic Details
Published inActa crystallographica. Section C, Crystal structure communications Vol. 52 ( Pt 6); p. 1583
Main Authors Deschamps, J R, George, C, Flippen-Anderson, J L
Format Journal Article
LanguageEnglish
Published United States 15.06.1996
Subjects
Amino Acid Sequence
Butanones - chemistry
Crystallization
Crystallography, X-Ray
Enkephalin, Leucine-2-Alanine - chemistry
Hydrogen Bonding
Models, Molecular
Molecular Sequence Data
Molecular Structure
Protein Conformation
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Summary:The title compound, L-tyrosyl-D-alanyl-glycyl-L-phenyl-alanyl-D-leucine hydrochloride (C29H40N5O7+. Cl-), co-crystallizes with 2-butanone (C4H8O). The structure determination reveals a slightly distorted type I' beta-bend conformation stabilized by one intramolecular hydrogen bond. This conformation is similar to that observed for other [Leu]-enkephalin analogues.
ISSN:0108-2701
DOI:10.1107/S0108270196000534